Since the outbreak of COVID-19 disease, a bidirectional interaction between kidney disease
and the progression of COVID-19 has been demonstrated. Kidney disease is an …

The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2 or megalin) is
representative of the phylogenetically conserved subfamily of giant LDL receptor-related …

Abstract Models of kidney injury have classically concentrated on glomeruli as the primary
site of injury leading to glomerulosclerosis or on tubules as the primary site of injury leading …

Proteinuria is a prominent feature of chronic kidney disease. Interventions that reduce
proteinuria slow the progression of chronic kidney disease and the associated risk of …

The multiligand receptors megalin (Lrp2) and cubilin (Cubn) and their endocytic adaptor
protein Dab2 (Dab2) play essential roles in maintaining the integrity of the apical endocytic …

Diabetic kidney disease (DKD) is characterized by progressive impairment of kidney
function. It has been postulated that tubule-interstitial injury, associated with tubular …

Fibrotic diseases affect multiple organs and are associated with morbidity and mortality. To
examine organ-specific and shared biologic mechanisms that underlie fibrosis in different …

Hearing loss affects nearly 1.6 billion people and is the third-leading cause of disability
worldwide. Chronic kidney disease (CKD) is also a common condition that is associated with …

Megalin is an endocytic receptor abundantly expressed in proximal tubular epithelial cells
and other calciotropic extrarenal cells expressing vitamin D metabolizing enzymes, such as …

The kidney proximal tubule (PT) efficiently recovers the low level of albumin and other
proteins that normally escape the glomerular filtration barrier. Two large receptors, megalin …