Molecular glue degraders: exciting opportunities for novel drug discovery
T Lemaitre, M Cornu, F Schwalen, M Since… - Expert Opinion on …, 2024 - Taylor & Francis
ABSTRACT Introduction Molecular Glue Degraders (MGDs) is a concept that refers to a
class of compounds that facilitate the interaction between two proteins or molecules within a …
class of compounds that facilitate the interaction between two proteins or molecules within a …
Trauma diagnostic-related target proteins and their detection techniques
YL Wei, X Ren, Z Yuan, J Hong, T Wang… - Expert reviews in …, 2024 - cambridge.org
Trauma is a significant health issue that not only leads to immediate death in many cases
but also causes severe complications, such as sepsis, thrombosis, haemorrhage, acute …
but also causes severe complications, such as sepsis, thrombosis, haemorrhage, acute …
An In vitro and in silico investigation of the antitrypanosomal activities of the stem bark extracts of Anopyxis klaineana (Pierre) Engl
L Adams, D Obiri-Yeboah, M Afiadenyo, S Hamidu… - Heliyon, 2024 - cell.com
African Trypanosomiasis caused by trypanosome parasites continues to be a major
neglected health problem, particularly in developing countries. Current treatments are …
neglected health problem, particularly in developing countries. Current treatments are …
Unraveling Psychedelic Responses: Targeted Protein Degradation and Genetic Diversity
RB Kargbo - ACS Medicinal Chemistry Letters, 2023 - ACS Publications
This Viewpoint discusses the intersection of targeted protein degradation (TPD)
technologies and psychedelic research. The resurgence in interest in psychedelics for …
technologies and psychedelic research. The resurgence in interest in psychedelics for …
Evaluation of the anti-trypanosoma activity of alkaloids from Pilocarpus microphyllus by molecular docking: A search for new drugs for Chagas disease
SS Nogueira… - …, 2024 - ojs.observatoriolatinoamericano …
Trypanosoma cruzi and Trypanosoma brucei, respectively, transmit the neglected tropical
diseases (NTDs) Chagas disease and sleeping sickness. They cause symptoms that are …
diseases (NTDs) Chagas disease and sleeping sickness. They cause symptoms that are …
PROTAC: Nouvelles stratégies thérapeutiques basées sur l'exploitation des voies de dégradation des protéines
M Cornu, T Lemaitre, F Schwalen, C Kieffer… - Biologie …, 2024 - biologie-journal.org
La perturbation de la protéostasie constitue un contexte propice à l'innovation
thérapeutique, en particulier grâce à l'exploitation de technologies comme l'approche …
thérapeutique, en particulier grâce à l'exploitation de technologies comme l'approche …