This Review focuses on the mechanistic evidence for a link between obesity, dysregulated
cellular metabolism and breast cancer. Strong evidence now links obesity with the …

Adiponectin is one of the most important adipocytokines secreted by adipocytes and is
called a “guardian angel adipocytokine” owing to its unique biological functions. Adiponectin …

Abstract Glycogen synthase kinase‐3 (GSK3) is a highly evolutionarily conserved
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …

The potential roles of breast cancer stem cells (BCSCs) in tumor initiation and recurrence
have been recognized for many decades. Due to their strong capacity for self-renewal and …

Adipose tissue is the largest endocrine organ and an accepted contributor to overall energy
homeostasis. There is strong evidence linking increased adiposity to the development of 13 …

The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and
studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular …

Adipose tissue is a complex organ with endocrine, metabolic and immune regulatory roles.
Adipose depots have been characterized to release several adipocytokines that work locally …

Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

The prevalence of obesity has been steadily increasing over the past few decades in several
developed and developing countries, with resultant hazardous health implications …

The effects of current treatment strategies for ischemic stroke are weakened by ischemia-
reperfusion (I/R) injury. Effective treatments targeting I/R injury are still insufficient …