Bioinformatics approaches to discovering food-derived bioactive peptides: Reviews and perspectives

Z Du, J Comer, Y Li - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Food-derived bioactive peptides (FBPs) are gaining interest due to their great potential in
agricultural byproduct valorization and high-activity peptide screening. The introduction of …

Polarizable force fields for biomolecular simulations: Recent advances and applications

Z Jing, C Liu, SY Cheng, R Qi, BD Walker… - Annual Review of …, 2019 - annualreviews.org
Realistic modeling of biomolecular systems requires an accurate treatment of electrostatics,
including electronic polarization. Due to recent advances in physical models, simulation …

Ion permeation, selectivity, and electronic polarization in fluoride channels

Z Yue, Z Wang, GA Voth - Biophysical Journal, 2022 - cell.com
Fluoride channels (Flucs) export toxic F− from the cytoplasm. Crystallography and
mutagenesis have identified several conserved residues crucial for fluoride transport, but the …

Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS)

SC Concilio, HR Zhekova, SY Noskov, SJ Russell - PloS one, 2020 - journals.plos.org
The sodium iodide symporter (NIS) transports iodide, which is necessary for thyroid
hormone production. NIS also transports other monovalent anions such as tetrafluoroborate …

Mapping of ion and substrate binding sites in human sodium iodide symporter (hNIS)

HR Zhekova, T Sakuma, R Johnson… - Journal of chemical …, 2020 - ACS Publications
The human sodium iodide symporter (hNIS) is a theranostic reporter gene which
concentrates several clinically approved SPECT and PET radiotracers and plays an …

[HTML][HTML] Role of SLC5A8 as a Tumor Suppressor in Cervical Cancer

O Vargas-Sierra, J Hernández-Juárez… - Frontiers in Bioscience …, 2024 - imrpress.com
Background: The SLC5A8 gene is silenced in various types of cancer, including cervical
cancer; we recently demonstrated that the SLC5A8 gene is also silenced in cervical cancer …

Diphenylene iodonium is a noncovalent MAO inhibitor: a biochemical and structural analysis

LG Iacovino, J Reis, A Mai, C Binda… - ChemMedChem, 2020 - Wiley Online Library
Diphenylene iodonium (DPI) is known for its inhibitory activities against many flavin‐and
heme‐dependent enzymes, and is often used as an NADPH oxidase inhibitor. We probed …

Sodium/Iodide Symporter Metastable Intermediates Provide Insights into Conformational Transition between Principal Thermodynamic States

M Chakrabarti, LM Amzel, AY Lau - The Journal of Physical …, 2023 - ACS Publications
The Sodium/Iodide Symporter (NIS), a 13-helix transmembrane protein found in the thyroid
and other tissues, transports iodide, a required constituent of thyroid hormones T3 and T4 …

Амиодарон-индуцированный тиреотоксикоз 2-го типа: предикторы и варианты терапии

АС Ермолаева, ОА Бякина, ЮП Сыч… - Альманах …, 2019 - cyberleninka.ru
Амиодарон-индуцированный тиреотоксикоз 2-го типа остается значимой проблемой
современной эндокринологии и кардиологии. Фармакологическая уникальность и …

Structural determinants of the dopamine transporter regulation mediated by G proteins

G Rojas, I Orellana, R Rosales-Rojas… - Journal of chemical …, 2020 - ACS Publications
Dopamine clearance in the brain is controlled by the dopamine transporter (DAT), a protein
residing in the plasma membrane, which drives reuptake of extracellular dopamine into …