In the last decades, the number of patients receiving chemotherapy has considerably
increased. Given the toxicity of cytotoxic agents to humans (not only for patients but also for …

Columns packed with sub-2μm totally porous and sub-3μm core–shell particles are very
widespread nowadays to conduct fast and efficient separations. In order to carry out really …

The number of patients suffering from cancer is constantly increasing and, consequently, the
number of different chemotherapy treatments administered is increasing. Given the high …

In the last few years, there have been a lot of advances in the field of liquid chromatography
(LC) and supercritical fluid chromatography (SFC). The intent of this review is to summarize …

Introduction: P-glycoprotein (P-gp) is a multi-specific efflux transporter belonging to ATP-
binding cassette (ABC) transporter family, encoded by the ABCB1 gene, which significantly …

Introduction: Piperine is a simple and pungent alkaloid found in the seeds of black pepper
(Piper nigrum). Following its isolation and full characterization, the biological properties of …

A simple, effective and suitable UFLC–ESI-MS/MS method was firstly developed to
simultaneously determine five characteristic constituents (piperine, piperlonguminine, Δα, β …

Background: P-glycoprotein (P-gp), a well known ATP dependent efflux membrane
transporter, has been attracting considerable interests of medical researchers due to its …

The alkaloids from Piper longum L. showed protective effects on Parkinson's disease
models in our previous study and piperine and piperlonguminine were the two main …

Alkaloids are biologically active compounds widely used as pharmaceuticals and
synthesised as secondary methabolites in plants. Many of these compounds are strongly …