Addictive drugs modify neurogenesis, synaptogenesis and synaptic plasticity to impair memory formation through neurotransmitter imbalances and signaling …

A Rezayof, Z Ghasemzadeh, OH Sahafi - Neurochemistry International, 2023 - Elsevier
Drug abuse changes neurophysiological functions at multiple cellular and molecular levels
in the addicted brain. Well-supported scientific evidence suggests that drugs negatively …

Role of microRNAs in the pathophysiology of addiction

AM Gowen, KE Odegaard, J Hernandez… - Wiley …, 2021 - Wiley Online Library
Addiction is a chronic and relapsing brain disorder characterized by compulsive seeking
despite adverse consequences. There are both heritable and epigenetic mechanisms …

Exploring the interplay of dopaminergic genotype and parental behavior in relation to executive function in early childhood

DM Vrantsidis, CAC Clark, A Volk… - Development and …, 2023 - cambridge.org
Child genotype is an important biologically based individual difference conferring differential
sensitivity to the effect of parental behavior. This study explored dopaminergic polygenic …

Genome-wide DNA methylation differences in nucleus accumbens of smokers vs. nonsmokers

CA Markunas, SA Semick, BC Quach, R Tao… - …, 2021 - nature.com
Numerous DNA methylation (DNAm) biomarkers of cigarette smoking have been identified
in peripheral blood studies, but because of tissue specificity, blood-based studies may not …

Investigating the influence of perinatal nicotine and alcohol exposure on the genetic profiles of dopaminergic neurons in the VTA using miRNA–mRNA analysis

T Kazemi, S Huang, NG Avci, CMK Waits, YM Akay… - Scientific reports, 2020 - nature.com
Nicotine and alcohol are two of the most commonly used and abused recreational drugs, are
often used simultaneously, and have been linked to significant health hazards. Furthermore …

MicroRNAs in methamphetamine-induced neurotoxicity and addiction

B Deng, Z Zhang, H Zhou, X Zhang, S Niu… - Frontiers in …, 2022 - frontiersin.org
Methamphetamine (METH) abuse remains a significant public health concern globally
owing to its strong addictive properties. Prolonged abuse of the drug causes irreversible …

Association between postnatal environmental tobacco smoke exposure controlling for prenatal exposure and conduct problems in children: A systematic review

AL Glenn, LK Ragno, J Liu - NeuroToxicology, 2023 - Elsevier
Prenatal exposure to environmental tobacco smoke (ETS) is commonly associated with
conduct problems in children. However, there is limited research on the effects of postnatal …

Association between environmental tobacco smoke exposure across the first four years of life and manifestation of externalizing behavior problems in school‐aged …

L Gatzke‐Kopp, MT Willoughby… - Journal of Child …, 2020 - Wiley Online Library
Background Extensive literature in human and animal models has documented an
association between maternal smoking during pregnancy and externalizing behavior in …

[HTML][HTML] Noncoding RNA therapeutics for substance use disorder

SA Seyednejad, GC Sartor - Advances in drug and alcohol …, 2022 - frontierspartnerships.org
Although noncoding RNAs (ncRNAs) have been shown to regulate maladaptive
neuroadaptations that drive compulsive drug use, ncRNA-targeting therapeutics for …

Nicotine as an Environmental Toxin: Implications for Children's Health

LM Gatzke-Kopp, DR Rice - Policy Insights from the …, 2023 - journals.sagepub.com
Despite significant declines in population smoking rates and effective policies to ban
smoking in public places, environmental exposure to nicotine remains prevalent among …