Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes
Genetically engineered mouse models are commonly preferred for studying the human
disease due to genetic and pathophysiological similarities between mice and humans. In …
disease due to genetic and pathophysiological similarities between mice and humans. In …
ZBTB transcription factors: key regulators of the development, differentiation and effector function of T cells
ZY Cheng, TT He, XM Gao, Y Zhao, J Wang - Frontiers in Immunology, 2021 - frontiersin.org
The development and differentiation of T cells represents a long and highly coordinated, yet
flexible at some points, pathway, along which the sequential and dynamic expressions of …
flexible at some points, pathway, along which the sequential and dynamic expressions of …
[HTML][HTML] LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6
Follicular helper T cells (T FH cells) are specialized effector CD4+ T cells that help B cells
develop germinal centers (GCs) and memory. However, the transcription factors that …
develop germinal centers (GCs) and memory. However, the transcription factors that …
[HTML][HTML] Common PIEZO1 allele in African populations causes RBC dehydration and attenuates plasmodium infection
Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood
cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced …
cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced …
Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation
T Sujino, M London, DP Hoytema van Konijnenburg… - Science, 2016 - science.org
Foxp3+ regulatory T cells in peripheral tissues (pTregs) are instrumental in limiting
inflammatory responses to nonself antigens. Within the intestine, pTregs are located …
inflammatory responses to nonself antigens. Within the intestine, pTregs are located …
Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture
T cell identity is established during thymic development, but how it is maintained in the
periphery remains unknown. Here we show that ablating Tcf1 and Lef1 transcription factors …
periphery remains unknown. Here we show that ablating Tcf1 and Lef1 transcription factors …
Crosstalk between ILC2s and Th2 cells varies among mouse models
RK Gurram, D Wei, Q Yu, MJ Butcher, X Chen, K Cui… - Cell reports, 2023 - cell.com
Summary Type 2 T helper (Th2) cells and group 2 innate lymphoid cells (ILC2s) provide
protection against helminth infection and are involved in allergic responses. However, their …
protection against helminth infection and are involved in allergic responses. However, their …
Tcf1 and Lef1 transcription factors establish CD8+ T cell identity through intrinsic HDAC activity
Abstract The CD4+ and CD8+ T cell dichotomy is essential for effective cellular immunity.
How individual T cell identity is established remains poorly understood. Here we show that …
How individual T cell identity is established remains poorly understood. Here we show that …
Wnt signaling in the regulation of immune cell and cancer therapeutics
Wnt signaling is one of the important pathways to play a major role in various biological
processes, such as embryonic stem-cell development, tissue regeneration, cell …
processes, such as embryonic stem-cell development, tissue regeneration, cell …
Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation
BJE Raveney, S Oki, H Hohjoh, M Nakamura… - Nature …, 2015 - nature.com
Abstract Development of acute experimental autoimmune encephalomyelitis (EAE) depends
on Th17 cells expressing the nuclear factor NR4A2. However, in mice lacking NR4A2 in T …
on Th17 cells expressing the nuclear factor NR4A2. However, in mice lacking NR4A2 in T …