Challenges in the integration of omics and non-omics data

E López de Maturana, L Alonso, P Alarcón… - Genes, 2019 - mdpi.com
Omics data integration is already a reality. However, few omics-based algorithms show
enough predictive ability to be implemented into clinics or public health domains. Clinical …

Genome-wide regression and prediction with the BGLR statistical package

P Pérez, G de Los Campos - Genetics, 2014 - academic.oup.com
Many modern genomic data analyses require implementing regressions where the number
of parameters (p, eg, the number of marker effects) exceeds sample size (n). Implementing …

Priors in whole-genome regression: the Bayesian alphabet returns

D Gianola - Genetics, 2013 - academic.oup.com
Whole-genome enabled prediction of complex traits has received enormous attention in
animal and plant breeding and is making inroads into human and even Drosophila genetics …

Machine learning methods and predictive ability metrics for genome-wide prediction of complex traits

O González-Recio, GJM Rosa, D Gianola - Livestock Science, 2014 - Elsevier
Genome-wide prediction of complex traits has become increasingly important in animal and
plant breeding, and is receiving increasing attention in human genetics. Most common …

Design of training populations for selective phenotyping in genomic prediction

D Akdemir, J Isidro-Sánchez - Scientific reports, 2019 - nature.com
Phenotyping is the current bottleneck in plant breeding, especially because next-generation
sequencing has decreased genotyping cost more than 100.000 fold in the last 20 years …

Germline variation in cancer-susceptibility genes in a healthy, ancestrally diverse cohort: implications for individual genome sequencing

DL Bodian, JN McCutcheon, P Kothiyal… - PloS one, 2014 - journals.plos.org
Technological advances coupled with decreasing costs are bringing whole genome and
whole exome sequencing closer to routine clinical use. One of the hurdles to clinical …

Accuracy of whole-genome prediction using a genetic architecture-enhanced variance-covariance matrix

Z Zhang, M Erbe, J He, U Ober, N Gao… - G3: Genes …, 2015 - academic.oup.com
Obtaining accurate predictions of unobserved genetic or phenotypic values for complex
traits in animal, plant, and human populations is possible through whole-genome prediction …

[HTML][HTML] Predicting bull fertility using genomic data and biological information

R Abdollahi-Arpanahi, G Morota… - Journal of Dairy Science, 2017 - Elsevier
The genomic prediction of unobserved genetic values or future phenotypes for complex
traits has revolutionized agriculture and human medicine. Fertility traits are undoubtedly …

Genome-wide association studies and genetic testing: understanding the science, success, and future of a rapidly developing field

L Baker, P Muir, SJ Sample - Journal of the American Veterinary …, 2019 - Am Vet Med Assoc
Dog owners are increasingly interested in using commercially available testing panels to
learn about the genetics of their pets, both to identify breed ancestry and to screen for …

Will big data close the missing heritability gap?

H Kim, A Grueneberg, AI Vazquez, S Hsu… - Genetics, 2017 - academic.oup.com
Modern biobanks that collect genotype-phenotype information from hundreds of thousands
of individuals bring unprecedented opportunities for genomic... Despite the important …