In mammals, excess energy is stored primarily as triglycerides, which are mobilized when
energy demands arise. This review mainly focuses on the role of long chain fatty acids …

Carbohydrate response element binding protein (ChREBP) is a carbohydrate-signaling
transcription factor that in the past years has emerged as a central metabolic regulator …

Microplastic particles (MP) has been detected in the environment widespread. Human
beings are inevitably exposed to MP via multiple routines. However, the hazard …

Fatty acid synthase (FAS) catalyzes the de novo synthesis of fatty acids. In the liver, FAS has
long been categorized as a housekeeping protein, producing fat for storage of energy when …

With the identification of ChREBP in 2001, our interest in understanding the molecular
control of carbohydrate sensing has surged. While ChREBP was initially studied as a master …

Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional
responses in metabolic tissues. Here we review advances in our understanding of the gene …

Carbohydrate metabolism is essential for cellular energy balance as well as for the
biosynthesis of new cellular building blocks. As animal nutrient intake displays temporal …

Objective—Hypertriglyceridemia and fatty liver are common in patients with type 2 diabetes,
but the factors connecting alterations in glucose metabolism with plasma and liver lipid …

The glucose-activated transcription factor carbohydrate response element binding protein
(ChREBP) induces the expression of hepatic glycolytic and lipogenic genes. The farnesoid …

The liver plays a key role in glucose homeostasis, lipid and energy metabolism. Its function
is primarily controlled by the anabolic hormone insulin and its counterparts glucagon …