Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding
and maturation whose expression is induced by heat shock or other stressors. The major …

Abstract Neem (Azadirachta indica A. Juss.), a versatile evergreen tree recognized for its
ethnopharmacological value, is a rich source of limonoids of the triterpenoid class, endowed …

The word “limonoids” originated from the bitterness of lemon or other citrus fruit. Structurally,
limonoids are formed by loss of four terminal carbons of the side chain in the apotirucallane …

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
Huntington's disease, amyotrophic lateral sclerosis and prion-based neurodegeneration are …

Living organisms are endowed with the capability to tackle various forms of cellular stress
due to the presence of molecular chaperone machinery complexes that are ubiquitous …

The purpose of this study is to investigate the efficacy and the mechanism of Hsp90
inhibition of Withaferin A (WA), a steroidal lactone occurring in Withania somnifera, in …

The 90-kDa heat-shock protein (Hsp90) is a molecular chaperone responsible for the
stability and function of a wide variety of client proteins that are critical for cell growth and …

Abstract The 90-kiloDalton (kD) heat shock protein (Hsp90) is a ubiquitous, ATP-dependent
molecular chaperone whose primary function is to ensure the proper folding of several …

Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly
in seeds. Several biological activities have been attributed to gedunin, including …

Covering: January 2006 to December 2008 This article reviews the antitumor and anti-HIV
activities of naturally occurring triterpenoids, including the lupane, ursane, oleanane …