Detection of minimal residual disease (MRD) has prognostic value in many hematologic
malignancies, including acute lymphoblastic leukemia, acute myeloid leukemia, chronic …

Chromosomal translocations (CTs) are hallmark mutations of hematopoietic malignancy that
result in the deregulated expression of oncogenes or the generation of novel fusion genes …

Gene fusions and their encoded products (fusion RNAs and proteins) are viewed as one of
the hallmarks of cancer. Traditionally, they were thought to be generated solely by …

Complex functioning of the genome in the cell nucleus is controlled at different levels:(a) the
DNA base sequence containing all relevant inherited information;(b) epigenetic pathways …

Chimeric gene products, most often resulting from chromosome translocations, have been
considered unique features of cancer, or at least of cells at high risk for becoming …

The term minimal residual disease (MRD) in its currently accepted application refers to low-
level disease detected in a whole variety of clinical situations. It is used to describe residual …

Although the prevalence of leukemia is increasing, the agents responsible for this increase
are not definitely known. While ionizing radiation (IR) was classified as a group one …

Endometrial stromal tumors (ESTs) are rare uterine mesenchymal tumors, comprising< 10%
of all uterine mesenchymal neoplasms. The latest World Health Organization classification …

In peripheral blood of at least 50% of healthy individuals, the translocations t (9; 22)
BCR/ABL, t (14; 18) IgH/BCL-2, t (2; 5) NPM-ALK and MLL duplications, which characterize …

There is clear evidence that ionizing radiation (IR) causes leukemia. For many types of
leukemia, the preleukemic fusion genes (PFG), as consequences of DNA damage and …