In their roles as major adhesion receptors, integrins signal across the plasma membrane in
both directions. Recent structural and cell biological data suggest models for how integrins …

Abstract αβ heterodimeric integrins mediate dynamic adhesive cell-cell and cell-extracellular
matrix (ECM) interactions in metazoa that are critical in growth and development …

Integrin α5β1 is a major fibronectin receptor critical for cell migration. Upon complex
formation, fibronectin and α5β1 undergo conformational changes. While this is key for cell …

In a recently developed human breast cancer model, treatment of tumor cells in a 3-
dimensional culture with inhibitory β1-integrin antibody or its Fab fragments led to a striking …

The structural basis for the divalent cation–dependent binding of heterodimeric αβ integrins
to their ligands, which contain the prototypical Arg-Gly-Asp sequence, is unknown …

Anchorage and growth factor independence are cardinal features of the transformed
phenotype. Although it is logical that the two pathways must be coregulated in normal …

Integrin receptors mediate cell adhesion, signal transduction, and cytoskeletal organization.
How a single transmembrane receptor can fulfill multiple functions was clarified by …

Introduction 3. Discussion 3.1. Fibronectin 3.2. Integrins 3.3. Molecular mechanisms of
ligand-integrin interactions 3.4. Ligand specificity of fibronectin binding integrins 3.5 …

Integrin α5β1 is a major cellular receptor for the extracellular matrix protein fibronectin and
plays a fundamental role during mammalian development. A crystal structure of the α5β1 …

In comparison to the internalization pathways of endocytosis, the recycling pathways are
less understood. Even less defined is the process of regulated recycling, as few examples …