As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …

Abstract Mitochondria contain about 1,000–1,500 proteins that fulfil multiple functions.
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …

Biogenesis of mitochondria requires the import of approximately 1,000 different precursor
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …

Eukaryotic cells must accurately monitor the integrity of the mitochondrial network to
overcome environmental insults and respond to physiological cues. The mitochondrial …

Protein homeostatic control of mitochondria is key to age-related diseases and organismal
decline. However, it is unknown how the diverse types of stress experienced by …

Thrombolytic therapy and revascularization strategies create a complete recanalization of
the occluded epicardial coronary artery in patients with myocardial infarction (MI). However …

Mitochondria are organelles with vital functions in almost all eukaryotic cells. Often
described as the cellular 'powerhouses' due to their essential role in aerobic oxidative …

Mitochondria, which serve as the energy factories of cells, are involved in cell differentiation,
calcium homeostasis, amino acid and fatty acid metabolism and apoptosis. In response to …

Protein import into mitochondria is a highly regulated process, yet how cells clear
mitochondria undergoing dysfunctional protein import remains poorly characterized. Here …

As organisms develop, individual cells generate mitochondria to fulfill physiological
requirements. However, it remains unknown how mitochondrial network expansion is scaled …