Natural products as anticancer agents: current status and future perspectives

A Naeem, P Hu, M Yang, J Zhang, Y Liu, W Zhu… - Molecules, 2022 - mdpi.com
Natural products have been an invaluable and useful source of anticancer agents over the
years. Several compounds have been synthesized from natural products by modifying their …

[HTML][HTML] Colon cancer and colorectal cancer: Prevention and treatment by potential natural products

MR Islam, S Akash, MM Rahman, FT Nowrin… - Chemico-biological …, 2022 - Elsevier
Colon cancer affects both men and women and is the world's second most significant cause
of cancer-related mortality. Colon cancer death rates have risen worldwide due to the …

[HTML][HTML] Natural products for treating colorectal cancer: A mechanistic review

X Huang, Z Yang, Q Xie, Z Zhang, H Zhang… - Biomedicine & …, 2019 - Elsevier
Colorectal cancer (CRC) is one of the most common types of cancers in humans and is
closely linked to the global cancer-related mortalities worldwide. Molecular pathological …

Potential of zerumbone as an anti-cancer agent

S Girisa, B Shabnam, J Monisha, L Fan, CE Halim… - Molecules, 2019 - mdpi.com
Cancer is still a major risk factor to public health globally, causing approximately 9.8 million
deaths worldwide in 2018. Despite advances in conventional treatment modalities for cancer …

[HTML][HTML] Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment

J Zhang, J Fan, X Zeng, M Nie, J Luan, Y Wang… - … Pharmaceutica Sinica B, 2021 - Elsevier
The Hedgehog (HH) signaling pathway plays important roles in gastrointestinal
carcinogenesis and the gastrointestinal tumor microenvironment (TME). Aberrant HH …

Zerumbone promotes cytotoxicity in human malignant glioblastoma cells through reactive oxygen species (ROS) generation

M Jalili-Nik, MM Sadeghi, E Mohtashami… - Oxidative medicine …, 2020 - Wiley Online Library
Glioblastoma multiforme (GBM) is the most hostile tumor in the central nervous system.
Unfortunately, the prognosis of GBM patients is poor following surgical interventions …

Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway

P Zhang, Y Zhang, K Liu, B Liu, W Xu, J Gao… - Cell …, 2019 - Wiley Online Library
Objectives The aim of study was to investigate the anticancer activities of Ivermectin (IVM)
and the possible mechanisms in cells level via cell proliferation inhibition, apoptosis and …

Polysaccharides from Lachnum sp. Inhibited colitis-associated colon tumorigenesis in mice by modulating fecal microbiota and metabolites

S Zong, H Ye, Z Ye, Y He, X Zhang, M Ye - International …, 2022 - Elsevier
It is still uncertain whether the consumption of Lachnum sp. polysaccharides (LEP) alleviates
colorectal cancer (CRC) through the gut microbiota. In this study, our efforts are focused on …

Zerumbone Protects against Carbon Tetrachloride (CCl4)-Induced Acute Liver Injury in Mice via Inhibiting Oxidative Stress and the Inflammatory Response: Involving …

M Wang, J Niu, L Ou, B Deng, Y Wang, S Li - Molecules, 2019 - mdpi.com
The natural compound Zerumbone (hereinafter referred to as ZER), a monocyclic
sesquiterpenoid, has been reported to possess many pharmacological properties, including …

Potential application of zerumbone in the prevention and therapy of chronic human diseases

YP Singh, S Girisa, K Banik, S Ghosh, P Swathi… - Journal of Functional …, 2019 - Elsevier
Several active compounds from 'Mother Nature'have been found to be tailor-made
therapeutics for the better management of numerous chronic ailments, with fewer adverse …