Interstitial cells: regulators of smooth muscle function

KM Sanders, SM Ward, SD Koh - Physiological reviews, 2014 - journals.physiology.org
Smooth muscles are complex tissues containing a variety of cells in addition to muscle cells.
Interstitial cells of mesenchymal origin interact with and form electrical connectivity with …

The enteric nervous system

KA Sharkey, GM Mawe - Physiological reviews, 2023 - journals.physiology.org
Of all the organ systems in the body, the gastrointestinal tract is the most complicated in
terms of the numbers of structures involved, each with different functions, and the numbers …

Abnormal absorptive colonic motor activity in germ-free mice is rectified by butyrate, an effect possibly mediated by mucosal serotonin

AD Vincent, XY Wang, SP Parsons… - American Journal …, 2018 - journals.physiology.org
The role of short-chain fatty acids (SCFAs) in the control of colonic motility is controversial.
Germ-free (GF) mice are unable to produce these metabolites and serve as a model to study …

Uterine telocytes: a review of current knowledge

I Roatesi, BM Radu, D Cretoiu… - Biology of …, 2015 - academic.oup.com
Telocytes (TCs), a novel cell type, are briefly defined as interstitial cells with telopodes (Tps).
However, a specific immunocytochemical marker has not yet been found; therefore, electron …

Neural regulation of slow waves and phasic contractions in the distal stomach: a mathematical model

ON Athavale, R Avci, AR Clark… - Journal of Neural …, 2024 - iopscience.iop.org
Objective. Neural regulation of gastric motility occurs partly through the regulation of gastric
bioelectrical slow waves (SWs) and phasic contractions. The interaction of the tissues and …

The role of telocytes in morphogenetic bioelectrical signaling: once more unto the breach

L Edelstein, J Smythies - Frontiers in molecular neuroscience, 2014 - frontiersin.org
Frontiers | The role of telocytes in morphogenetic bioelectrical signaling: once more unto the
breach Skip to main content Download Article Download Article Download PDF ReadCube …

Antibiotic driven changes in gut motility suggest direct modulation of enteric nervous system

T Delungahawatta, JY Amin, AM Stanisz… - Frontiers in …, 2017 - frontiersin.org
Antibiotic-mediated changes to the intestinal microbiome have largely been assumed to be
the basis of antibiotic-induced neurophysiological and behavioral changes. However …

Telocytes in the human sinoatrial node

LB Mitrofanova, AN Gorshkov… - Journal of cellular …, 2018 - Wiley Online Library
The sinoatrial node (SAN) is composed mostly of pacemaker, transitional and Purkinje‐like
cells. Pacemaker cells, especially in the centre of the SAN, are surrounded by dense fibrous …

Network properties of interstitial cells of Cajal affect intestinal pacemaker activity and motor patterns, according to a mathematical model of weakly coupled oscillators

R Wei, SP Parsons, JD Huizinga - Experimental Physiology, 2017 - Wiley Online Library
New Findings What is the central question of this study? What are the effects of interstitial
cells of Cajal (ICC) network perturbations on intestinal pacemaker activity and motor …

ELP1, the Gene Mutated in Familial Dysautonomia, Is Required for Normal Enteric Nervous System Development and Maintenance and for Gut Epithelium …

M Chaverra, AM Cheney, A Miller, L George… - Journal of …, 2024 - jneurosci.org
Familial dysautonomia (FD) is a rare sensory and autonomic neuropathy that results from a
mutation in the ELP1 gene. Virtually all patients report gastrointestinal (GI) dysfunction and …