Although the administration of fluid is the first treatment considered in almost all cases of
circulatory failure, this therapeutic option poses two essential problems: the increase in …

Venous return is the flow of blood from the systemic venous network towards the right heart.
At steady state, venous return equals cardiac output, as the venous and arterial systems …

During septic shock, fluid therapy is aimed at increasing cardiac output and improving tissue
oxygenation, but it poses two problems: it has inconsistent and transient efficacy, and it has …

In this review, we aimed to comprehensively summarize current literature on
pathophysiology, relevance, diagnosis and treatment of fluid accumulation in patients with …

During septic shock, vasopressor infusion is usually started only after having corrected the
hypovolaemic component of circulatory failure, even in the most severe patients. However …

Septic shock is a common condition associated with hypotension and organ dysfunction. It is
associated with high mortality rates of up to 60% despite the best recommended …

Septic shock is mainly characterized—in addition to hypovolemia—by vasoplegia as a
consequence of a release of inflammatory mediators. Systemic vasodilatation due to …

El shock séptico (SS) es una complicación frecuentemente asociada a la sepsis con una
mortalidad elevada. El inicio precoz del tratamiento vasopresor, incluso antes de finalizar la …

OBJECTIVES: To identify research priorities in the management, epidemiology, outcome,
and pathophysiology of sepsis and septic shock. DESIGN: Shortly after publication of the …

Oxygen is needed to generate aerobic adenosine triphosphate and energy that is required
to support vital cellular functions. Oxygen delivery (DO 2) to the tissues is determined by …