Neuronal membrane excitability must be resilient to perturbations that can take place over
timescales from milliseconds to months (or even years in long-lived animals). A great deal of …

Due to its complex and multifaceted nature, developing effective treatments for epilepsy is
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …

Neurons maintain their average firing rate and other properties within narrow bounds
despite changing conditions. This homeostatic regulation is achieved using negative …

Pain-related sensory input is processed in the spinal dorsal horn (SDH) before being
relayed to the brain. That processing profoundly influences whether stimuli are correctly or …

Neurons encounter unavoidable evolutionary trade-offs between multiple tasks. They must
consume as little energy as possible while effectively fulfilling their functions. Cells …

In this study, we develop new reverse engineering (RE) techniques to identify the
organization of the synaptic inputs generating firing patterns of populations of neurons. We …

Nociceptive sensory neurons convey pain-related signals to the CNS using action
potentials. Loss-of-function mutations in the voltage-gated sodium channel Na V 1.7 cause …

Neural network flexibility includes changes in neuronal participation between networks,
such as the switching of neurons between single-and dual-network activity. We previously …

Abstract Concepts from network science and graph theory, including the framework of
network motifs, have been frequently applied in studying neuronal networks and other …

Heterogeneity is omnipresent across all living systems. Diversity enriches the dynamical
repertoire of these systems but remains challenging to reconcile with their manifest …