Heterotrimeric G protein signaling without GPCRs: The Gα-binding-and-activating motif
M Garcia-Marcos - Journal of Biological Chemistry, 2024 - ASBMB
Heterotrimeric G proteins (Gαβγ) are molecular switches that relay signals from 7-
transmembrane receptors located at the cell surface to the cytoplasm. The function of these …
transmembrane receptors located at the cell surface to the cytoplasm. The function of these …
A circuit for secretion‐coupled cellular autonomy in multicellular eukaryotic cells
Cancers represent complex autonomous systems, displaying self‐sufficiency in growth
signaling. Autonomous growth is fueled by a cancer cell's ability to “secrete‐and‐sense” …
signaling. Autonomous growth is fueled by a cancer cell's ability to “secrete‐and‐sense” …
Regulation of DNA damage response by trimeric G-proteins
Upon sensing DNA double-strand breaks (DSBs), eukaryotic cells either die or repair DSBs
via one of the two competing pathways, ie, non-homologous end-joining (NHEJ) or …
via one of the two competing pathways, ie, non-homologous end-joining (NHEJ) or …
[PDF][PDF] GIV 对脑缺血/再灌注损伤模型中神经炎症反应的影响
陈明， 石鹏， 夏明燕， 龙婷婷， 禹文峰 - 安徽医科大学学报, 2023 - aydxb.cn
摘要目的探讨包含88A 的卷曲螺旋结构域蛋白GIV 是否对脑缺血再灌注损伤模型中的神经炎症
应答反应有影响. 方法构建C57BL/6 小鼠的大脑中动脉栓塞再灌注模型(MACO/R) 及BV2 …
应答反应有影响. 方法构建C57BL/6 小鼠的大脑中动脉栓塞再灌注模型(MACO/R) 及BV2 …
[HTML][HTML] GIV is a promising novel poor prognostic factor in liver hepatocellular carcinoma
Z Zou, Y Sun, L Wang, S Ma, C Sun, Y Zhou, G Yang - Medicine, 2022 - journals.lww.com
Numerous studies have implicated Gα-interacting, vesicle-associated protein (GIV) in the
development and metastasis of various cancers. However, its role remains unclear in liver …
development and metastasis of various cancers. However, its role remains unclear in liver …
A Multiomic Analysis Reveals How Breast Cancers Disseminated to the Bone Marrow Acquire Aggressive Phenotypes through Tumor-Stroma Tunnels
Abstract Estrogen receptor-positive (ER+) breast cancer commonly disseminates to bone
marrow, where interactions with mesenchymal stromal cells (MSCs) shape disease …
marrow, where interactions with mesenchymal stromal cells (MSCs) shape disease …
GIV/Girdin binds BRCA1 and links trimeric G-proteins to DNA damage response
AA Abd El-Hafeez, N Sun, A Chakraborty, J Ear, S Roy… - bioRxiv, 2021 - biorxiv.org
Upon sensing DNA double-strand breaks (DSBs), eukaryotic cells either die or repair DSBs
via one of two competing pathways, ie, non-homologous end-joining (NHEJ) or homologous …
via one of two competing pathways, ie, non-homologous end-joining (NHEJ) or homologous …
A Circuit for Secretion-coupled Cellular Autonomy in Multicellular Eukaryotes
Cancers represent complex autonomous systems, displaying self-sufficiency in growth
signaling. Autonomous growth is fueled by a cancer cell's ability to 'secrete-and …
signaling. Autonomous growth is fueled by a cancer cell's ability to 'secrete-and …
Coupling of NOD2 to GIV is Required for Bacterial Sensing
Sensing of pathogens by Nucleotide oligomerization domain (NOD)-like 2 receptor (NOD2)
induces a protective inflammatory response that coordinates bacterial clearance …
induces a protective inflammatory response that coordinates bacterial clearance …
[PDF][PDF] Regulation of DNA damage response by trimeric G-protein Signaling
AA Abd El-Hafeez, N Sun, A Chakraborty, J Ear, S Roy… - scholar.archive.org
Genomic integrity is under constant attack from extrinsic and intrinsic factors that induce
DNA damage (1). Damaged DNA must be repaired to maintain genomic integrity via …
DNA damage (1). Damaged DNA must be repaired to maintain genomic integrity via …