Abstract Interleukin-33 (IL-33)—a member of the IL-1 family—was originally described as an
inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now …

Interleukin-33 (IL-33) is a nuclear-associated cytokine of the IL-1 family originally described
as a potent inducer of allergic type 2 immunity. IL-33 signals via the receptor ST2, which is …

Innate cells are responsible for the rapid recognition of infection and mediate essential
mechanisms of pathogen elimination, and also facilitate adaptive immune responses. We …

The intestinal lumen harbors nearly 100 trillion commensal bacteria that exert crucial
function for health. An elaborate balance between immune responses and tolerance to …

Non-muscle–invasive bladder cancer (NMIBC) is a highly recurrent tumor despite
intravesical immunotherapy instillation with the bacillus Calmette-Guérin (BCG) vaccine. In a …

Immunity to many human and murine gastrointestinal helminth parasites requires interleukin-
4 (IL-4)-directed type 2 helper (TH 2) differentiation of CD4+ T cells to elicit type-2 immunity …

Tissue healing and regeneration is a complex, choreographed, spatiotemporal process
involving a plethora of cell types, the activity of which is stringently regulated in order for …

Although traumatic brain injury (TBI) is a common cause of death and disability worldwide,
there is currently a lack of effective therapeutic drugs and targets. To reveal the complex …

Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …

With the advent of an aging society, the incidence of dementia is increasing, resulting in a
vast burden on society. It is increasingly acknowledged that neuroinflammation is implicated …