The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

Whereas the study of the interactions between the immune system and the central nervous
system (CNS) has often focused on pathological conditions, the importance of neuroimmune …

Secreted extracellular vesicles (EVs) influence the tumor microenvironment and promote
distal metastasis. Here we analyzed the involvement of melanoma-secreted EVs in lymph …

The lymphatic system plays critical roles in tissue fluid homeostasis and immunity and has
been implicated in the development of many different pathologies, ranging from …

During aging, visceral adiposity is often associated with alterations in adipose tissue (AT)
leukocytes, inflammation, and metabolic dysfunction. However, the contribution of AT B cells …

T cell migration within and between peripheral tissues and secondary lymphoid organs is
essential for proper functioning of adaptive immunity. While active T cell migration within a …

Generalized lymphatic anomaly (GLA) is a vascular disorder characterized by diffuse or
multifocal lymphatic malformations (LMs). The etiology of GLA is poorly understood. We …

Tertiary lymphoid organs (TLOs) are accumulations of lymphoid cells in chronic
inflammation that resemble LNs in their cellular content and organization, high endothelial …

Lymphatic vasculature regulates fluid homeostasis by returning interstitial fluid to blood
circulation. Lymphatic endothelial cells (LECs) are the building blocks of the entire lymphatic …

The mammalian lymphatic vasculature is important for returning fluids from the extracellular
tissue milieu back to the blood circulation. We showed previously that Prox1 dosage is …