Rett syndrome (RTT) is a severe and progressive neurological disorder, which mainly affects
young females. Mutations of the methyl-CpG binding protein 2 (MECP2) gene are the most …

Rett Syndrome (RTT) is a severe, rare, and progressive developmental disorder with
patients displaying neurological regression and autism spectrum features. The affected …

MECP2 gene transfer has been shown to extend the survival of Mecp2−/y knockout mice
modelling Rett syndrome, an X-linked neurodevelopmental disorder. However, controlling …

Herpes simplex virus (HSV) is the main cause of viral encephalitis in the Western world, and
the type I interferon (IFN) system is important for antiviral control in the brain. Here, we have …

Rare diseases are very difficult to study mechanistically and to develop therapies for
because of the scarcity of patients. Here, the rare neuro-metabolic disorder Rett syndrome …

Loss-and gain-of-function mutations in methyl-CpG-binding protein 2 (MECP2) underlie two
distinct neurological syndromes with strikingly similar features, but the synaptic and circuit …

Epigenetic processes in the brain involve the transfer of information arising from short-lived
cellular signals and changes in neuronal activity into lasting effects on gene expression. Key …

Intravenous administration of adeno-associated virus serotype 9 (AAV9)/hMECP2 has been
shown to extend the lifespan of Mecp2−/y mice, but this delivery route induces liver toxicity in …

Since the discovery of its fundamental involvement in Rett syndrome, methyl CpG binding
protein 2 (MeCP2) has been the focus of an exhaustive biochemical and functional …

Genetic mutations of the Methyl-CpG-binding protein-2 (MECP2) gene underlie Rett
syndrome (RTT). Developmental processes are often considered to be irrelevant in RTT …