Multi-layered transcriptomic analysis reveals a pivotal role of FMR1 and other developmental genes in Alzheimer's disease-associated brain ceRNA network

RM Piergiorge, RSF Junior… - Computers in Biology …, 2023 - Elsevier
Alzheimer's disease (AD) is an increasingly neurodegenerative disorder that causes
progressive cognitive decline and memory impairment. Despite extensive research, the …

CoGTEx: Unscaled system-level coexpression estimation from GTEx data forecast novel functional gene partners

MA Cortes-Guzman, V Treviño - PloS one, 2024 - journals.plos.org
Motivation Coexpression estimations are helpful for analysis of pathways, cofactors,
regulators, targets, and human health and disease. Ideally, coexpression estimations should …

Quantitative in vitro to in vivo extrapolation for human toxicology and drug development

L Cattelani, G del Giudice, A Serra, M Fratello… - arXiv preprint arXiv …, 2024 - arxiv.org
Traditional animal testing for toxicity is expensive, time consuming, ethically questioned,
sometimes inaccurate because of the necessity to extrapolate from animal to human, and in …

IT-Enabled WGCNA for Critical Gene Module Mapping and Therapy Optimization: Advancing Leukemia Care

R Kapçiu, B Preni, E Kalluçi - Transdisciplinary Journal of Engineering …, 2024 - atlas-tjes.org
Acquiring a profound comprehension of the complex correlation between genes is essential
for progressing treatment and diagnostics in acute leukemia research. This work utilizes …

[PDF][PDF] Identification of Specific Gene Modules and Candidate Signatures in Necrotizing Enterocolitis Disease: Network-based Gene Co-expression Approach

MR Auwul, C Zhang, MR Rahman… - Biointerface Research in …, 2021 - academia.edu
Necrotizing enterocolitis (NEC) is a serious disease of the gastrointestinal systems that
primarily affects premature newborns' intestine in neonatal intensive care units. The present …

Deciphering Trans-acting Regulatory Molecular Mechanisms with Machine Learning

TS Akcan - 2023 - mediatum.ub.tum.de
This dissertation addresses two biological challenges by employing machine learning
methods on large-scale multi-omics data focusing specifically on 1) the identification of …

[PDF][PDF] Analýza tkáňové exprese proteomu cervikálního hlenu

J Vodička, J Dostál, D Holub, R Pilka, P Džubák… - Ceska …, 2023 - researchgate.net
Cervical mucus is a viscous fluid functioning as a cervix plug. Products of the endometrial
and cervical glands can be detected in the cervical mucus. Cervical mucus is further …