Triazolothiadiazoles and triazolothiadiazines–Biologically attractive scaffolds
Contemporary medicinal chemistry faces diverse challenges from several directions,
including the need for both potency and specificity of any therapeutic agent. Therefore, in the …
including the need for both potency and specificity of any therapeutic agent. Therefore, in the …
Synthesis, crystal structure and biological evaluation of some novel 1, 2, 4-triazolo [3, 4-b]-1, 3, 4-thiadiazoles and 1, 2, 4-triazolo [3, 4-b]-1, 3, 4-thiadiazines
Nitrogen-containing heterocycles are of particular interest and significant importance for the
discovery of potent bioactive agents in pharmaceutical industry. The present study reports …
discovery of potent bioactive agents in pharmaceutical industry. The present study reports …
Synthetic and biological aspects of thiadiazoles and their condensed derivatives: an overview
The three heteroatoms containing five membered heterocycles such as thiadiazoles have
been extensively studied due to their important pharmacological activities. The thiadiazole …
been extensively studied due to their important pharmacological activities. The thiadiazole …
Triazolothiadiazoles and Triazolothiadiazines as New and Potent Urease Inhibitors: Insights from In Vitro Assay, Kinetics Data, and In Silico Assessment
Hyperactivity of the urease enzyme induces the pathogenesis of peptic ulcers and gastritis.
The identification of new urease inhibitors can reduce the activity of urease. Therefore, in the …
The identification of new urease inhibitors can reduce the activity of urease. Therefore, in the …
Synthesis, analgesic, anti-inflammatory and antimicrobial studies of 2, 4-dichloro-5-fluorophenyl containing thiazolotriazoles
MS Karthikeyan - European journal of medicinal chemistry, 2009 - Elsevier
A series of 2, 4-dichloro-5-fluorophenyl containing thiazolotriazoles (1) were synthesized
starting from 3-(2, 4-dichloro-5-fluorophenyl)-4H-1, 2, 4-triazole-3-thiol (5). The newly …
starting from 3-(2, 4-dichloro-5-fluorophenyl)-4H-1, 2, 4-triazole-3-thiol (5). The newly …
[HTML][HTML] 6-[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]-3-[(2-naphthyloxy) methyl][1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazole as a potent antioxidant and an anticancer agent …
In this paper we have investigated the in vitro antioxidant property of two triazolo-
thiadiazoles, 6-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]-3-[(2-naphthyloxy) methyl][1, 2, 4] …
thiadiazoles, 6-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]-3-[(2-naphthyloxy) methyl][1, 2, 4] …
Exploration of a library of triazolothiadiazole and triazolothiadiazine compounds as a highly potent and selective family of cholinesterase and monoamine oxidase …
There is a high demand for the collection of small organic molecules (especially N-
heterocycles) with diversity and complexity in the process of drug discovery. This need for …
heterocycles) with diversity and complexity in the process of drug discovery. This need for …
[HTML][HTML] Synthesis and pharmacological evaluation of 3-diphenylmethyl-6-substituted-1, 2, 4-triazolo [3, 4-b]-1, 3, 4-thiadiazoles: A condensed bridgehead nitrogen …
Abstract A series of 3-diphenylmethyl-6-substituted-1, 2, 4-triazolo [3, 4-b]-1, 3, 4-thiadiazole
derivatives (4a–j and 5a–d) were synthesized by condensation of 4-amino-5-diphenylmethyl …
derivatives (4a–j and 5a–d) were synthesized by condensation of 4-amino-5-diphenylmethyl …
An overview on 1, 2, 4-triazole and 1, 3, 4-thiadiazole derivatives as potential anesthesic and anti-inflammatory agents
The aim. The purpose of this review is to summarize data on the synthesis and structural
modification of heterocyclic systems with triazole and thiadiazole fragments in molecules as …
modification of heterocyclic systems with triazole and thiadiazole fragments in molecules as …
SAR studies on 1, 2, 4-triazolo [3, 4-b][1, 3, 4] thiadiazoles as inhibitors of Mtb shikimate dehydrogenase for the development of novel antitubercular agents
Z Li, Y Liu, X Bai, Q Deng, J Wang, G Zhang, C Xiao… - RSC …, 2015 - pubs.rsc.org
Shikimate dehydrogenase, an essential protein for the biosynthesis of the chorismate end
product, is a highly promising therapeutic target, especially for the discovery and …
product, is a highly promising therapeutic target, especially for the discovery and …