Gliomas are heterogeneous tumours derived from glial cells and remain the deadliest form
of brain cancer. Although the glioma stem cell sits at the apex of the cellular hierarchy, how it …

Astrocytes are the most abundant cell type in the central nervous system and have diverse
functions in blood–brain barrier maintenance, neural circuitry formation and function, and …

The coordinated spatial and temporal regulation of gene expression in the vertebrate neural
tube determines the identity of neural progenitors and the function and physiology of the …

The molecular mechanisms that produce the full array of neuronal subtypes in the vertebrate
nervous system are incompletely understood. Here, we provide evidence of a global …

Glioblastoma frequently exhibits therapy-associated subtype transitions to mesenchymal
phenotypes with adverse prognosis. Here, we perform multi-omic profiling of 60 …

The development of the vertebrate spinal cord involves the formation of the neural tube and
the generation of multiple distinct cell types. The process starts during gastrulation …

Astrocytes are critical for the development and function of the central nervous system. In
developing brains, immature astrocytes undergo morphological, molecular, cellular, and …

Disruptions to developmental cell signaling pathways and transcriptional cascades have
been implicated in tumor initiation, maintenance and progression. Resurgence of aberrant …

Gliomas are brain and spinal cord malignancies characterized by high malignancy, high
recurrence and poor prognosis, the underlying mechanisms of which remain largely elusive …

Epigenetic dysregulation is a universal feature of cancer that results in altered patterns of
gene expression that drive malignancy. Brain tumors exhibit subtype-specific epigenetic …