Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare, autosomal-dominant, and fatal
premature aging syndrome. HGPS is most often derived from a de novo point mutation in the …

Nuclear deformation, a hallmark frequently observed in senescent cells, is presumed to be
associated with the erosion of chromatin organization at the nuclear periphery. However …

Several premature aging mouse models have been developed to study aging and identify
interventions that can delay age‐related diseases. Yet, it is still unclear whether these …

Abstract Telomere Biology Disorders (TBDs) are characterized by mutations in telomere-
related genes leading to short telomeres and premature aging but with no strict correlation …

Berardinelli–Seip congenital lipodystrophy type 2 (CGL2) is a very rare human genetic
disorder with potential significance to the understanding of the pathobiology of aging. CGL2 …

Background: Twelve separate streams of empirical data make a strong case for cannabis-
induced accelerated aging including hormonal, mitochondriopathic, cardiovascular …

Background Down Syndrome (DS) is the most common chromosome anomaly in humans
and occurs due to an extra copy of chromosome 21. The malignancy profile in DS is unique …

Background Aging has been reported as a major risk factor for severe symptoms and higher
mortality rates in COVID-19 patients. Molecular hallmarks such as epigenetic alterations and …

As global interest in the therapeutic potential of cannabis and its' derivatives for the
management of selected diseases increases, it is increasingly imperative that the toxic …