Preconditioning is hormesis part I: Documentation, dose-response features and mechanistic foundations

EJ Calabrese - Pharmacological Research, 2016 - Elsevier
This article provides the first extensive documentation of the dose response features of pre-
and postconditioning. Pre-and postconditioning studies with rigorous study designs, using …

Neuregulin in cardiovascular development and disease

O Odiete, MF Hill, DB Sawyer - Circulation research, 2012 - Am Heart Assoc
Studies in genetically modified mice have demonstrated that neuregulin-1 (NRG-1), along
with the erythroblastic leukemia viral oncogene homolog (ErbB) 2, 3, and 4 receptor tyrosine …

Land for welfare in China

M Cai - Land Use Policy, 2016 - Elsevier
Drawing on firsthand observations, Party and government documents, and survey data, this
study examines the causes and processes of the land for welfare policy in China. The …

Neuregulin-1, a potential therapeutic target for cardiac repair

Y Wang, J Wei, P Zhang, X Zhang, Y Wang… - Frontiers in …, 2022 - frontiersin.org
NRG1 (Neuregulin-1) is an effective cardiomyocyte proliferator, secreted and released by
endothelial vascular cells, and affects the cardiovascular system. It plays a major role in …

Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease

A Geissler, S Ryzhov, DB Sawyer - Clinical Science, 2020 - portlandpress.com
Neuregulins (NRGs) are protein ligands that act through ErbB receptor tyrosine kinases to
regulate tissue morphogenesis, plasticity, and adaptive responses to physiologic needs in …

4-Dimensional light-sheet microscopy to elucidate shear stress modulation of cardiac trabeculation

J Lee, P Fei, RRS Packard, H Kang… - The Journal of …, 2016 - Am Soc Clin Investig
Hemodynamic shear forces are intimately linked with cardiac development, during which
trabeculae form a network of branching outgrowths from the myocardium. Mutations that …

Mechanisms of the multitasking endothelial protein NRG-1 as a compensatory factor during chronic heart failure

GW De Keulenaer, E Feyen, L Dugaucquier… - Circulation: Heart …, 2019 - Am Heart Assoc
Heart failure is a complex syndrome whose phenotypic presentation and disease
progression depends on a complex network of adaptive and maladaptive responses. One of …

The roles of neuregulin-1 in cardiac development, homeostasis, and disease: supplementary issue: stem cell biology

CE Rupert, KLK Coulombe - Biomarker insights, 2015 - journals.sagepub.com
Neuregulin-1 (NRG-1) and its signaling receptors, erythroblastic leukemia viral oncogene
homologs (ErbB) 2, 3, and 4, have been implicated in both cardiomyocyte development and …

MicroRNAs target the PI3K/Akt/p53 and the Sirt1/Nrf2 signaling pathways in doxorubicin‐induced cardiotoxicity

F Yarmohammadi, Z Ebrahimian… - Journal of Biochemical …, 2023 - Wiley Online Library
Doxorubicin (DOX) is used as a chemotherapeutic agent in the treatment of solid tumors.
Irreversible cardiotoxicity is the major limitation in the clinical use of DOX. Several …

ErbB2 signaling at the crossing between heart failure and cancer

Z Vermeulen, VFM Segers… - Basic research in …, 2016 - Springer
The dual role of ErbB2 (or HER-2) in tumor growth and in physiological adaptive reactions of
the heart positions ErbB2 at the intersection between cancer and chronic heart failure …