Circadian and diurnal variation in cerebral blood flow directly contributes to the diurnal
variation in the risk of stroke, either through factors that trigger stroke or due to impaired …

Background Cerebral small vessel disease (cSVD) is a major contributing factor to ischemic
stroke and dementia. However, the vascular pathologies of cSVD remain inconclusive. The …

Objective Cerebral small vessel diseases (cSVDs) are a major cause of stroke and
dementia. We used cutting‐edge 7T‐MRI techniques in patients with Cerebral Autosomal …

Background: Cerebral amyloid angiopathy (CAA) is associated with cognitive decline. CAA
has diverse impacts on brain structure and function; however, the brain lesions that mediate …

Cerebral small vessel disease (cSVD), a common cause of stroke and dementia, is
traditionally considered the small vessel equivalent of large artery occlusion or rupture that …

Cerebral small vessel disease (cSVD) causes lacunar stroke (25% of ischaemic strokes),
haemorrhage, dementia, physical frailty, or is 'covert', but has no specific treatment …

BACKGROUND: Cerebral small vessel disease is a common cause of vascular cognitive
impairment and dementia. There is an urgent need for preventative treatments for vascular …

Neurodegenerative diseases (NDs) cause progressive loss of neuron structure and
ultimately lead to neuronal cell death. Since the available drugs show only limited …

Diabetes is a major risk factor for all types of dementia. The underlying reasons are not fully
understood, and preventive therapeutic strategies are lacking. Previously we have shown …

Background: Cerebral pulsatility is thought to reflect arterial stiffness and downstream
microvascular resistance. Although previous studies indicated cerebral pulsatility might …