Cancer is a key health issue across the world, causing substantial patient morbidity and
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …

Pancreatic cancer is one of the most lethal malignancies worldwide. Although the standard
of care in pancreatic cancer has improved, prognoses for patients remain poor with a 5-year …

Background Neutrophil extracellular traps (NETs) were originally thought to be formed by
neutrophils to trap invading microorganisms as a defense mechanism. Increasing studies …

Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …

Metastasis is a distinct stage of cancer progression that requires the development of
angiogenic blood vessels serving as conduits for tumor cell dissemination. An accumulated …

Background Several studies have reported that the systemic immune-inflammation index
(SII) is associated with the prognosis of patients with urologic cancers (UCs). The aim of this …

The presence of neutrophils in tumors has traditionally been considered to be indicative of a
failed immune response against cancers. However, there is now evidence showing that …

Mesenchymal gastrointestinal cancers are represented by the gastrointestinal stromal
tumors (GISTs) which occur throughout the whole gastrointestinal tract, and affect human …

A proangiogenic function of tissue-infiltrating monocytes/macrophages has long been
attributed to their matrix metalloproteinase-9 zymogen (proMMP-9). Herein, we evaluated …

Tissue healing and regeneration is a complex, choreographed, spatiotemporal process
involving a plethora of cell types, the activity of which is stringently regulated in order for …