Mortality from myocardial infarction (MI) has declined over recent decades, which could be
attributed in large part to improved treatment methods. Early reperfusion is the cornerstone …

Only a few preclinical findings are confirmed in the clinic, posing a critical issue for clinical
development. Therefore, identifying the best preclinical models can help dissect molecular …

Many aspects of metabolism are sex-biased, from gene expression in metabolic tissues to
the prevalence and presentation of cardiometabolic diseases. The influence of hormones …

Major risk factors of cardiovascular disease (CVD) include hypertension, obesity, diabetes
mellitus and metabolic syndrome; all of which are considered inflammatory conditions …

Lipid-lowering therapy (LLT) is a cornerstone of atherosclerotic cardiovascular disease
prevention. Although LLT might lead to different reductions in low-density lipoprotein …

Aim: The frequencies of SLCO1B1* 5 and CYP2C9* 2 and* 3 in specific Asian, Native
Hawaiian and Pacific Islander (NHPI) subgroups are unknown. Patients & methods …

Early-life conditions such as prenatal nutrition can have long-term effects on metabolic
health, and these effects may differ between males and females. Understanding the …

Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women
are more likely than men to experience adverse statin effects, particularly new-onset …

Pronounced sex differences in the development and outcome of cardiovascular diseases
(CVD) exist. Apolipoprotein A1 (APOA1), the basic structural protein of high-density …

There is increasing appreciation that sex differences are not limited to reproductive organs
or traits related to reproduction and that sex is an important biological variable in most …