The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …

The past two decades have witnessed a dramatic accumulation of evidence indicating that
the excitatory amino acid glutamate plays an important role in drug addiction and …

The role of endocannabinoid (eCB) signalling in restraint stress‐induced neuronal activation
was studied. Male mice exposed to 30 min of restraint exhibit increased Fos protein within …

Considerable evidence suggests that neuroadaptations leading to addiction involve the
same glutamate-dependent cellular mechanisms that enable learning and memory. Long …

Although metabotropic glutamate receptor 5 (mGluR5) is essential for cocaine self-
administration and drug-seeking behavior, there is limited knowledge of the cellular actions …

Adolescence comes in association with puberty, when maturation and rearrangement of
major neurotransmitter pathways and functions are still taking place. The neurobiological …

Marijuana and its psychoactive constituents induce a multitude of effects on brain function.
These include deficits in memory formation, but care needs to be exercised since many …

The endogenous cannabinoid transmitter system regulates synaptic transmission
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …

Rationale Cannabis abuse and endocannabinoids are associated to schizophrenia.
Objectives It is important to discern the association between schizophrenia and exogenous …

Recent reports have demonstrated that disruption of CB 1 receptor signaling impairs
extinction of learned responses in conditioned fear and Morris water maze paradigms. Here …