Fluorescence spectroscopy, one of the most informative and sensitive analytical techniques,
has played and continues to play key roles in modern research. Indeed, unraveling the inner …

While natural and synthetic N-nucleosides are vulnerable to enzymatic and acid-catalyzed
hydrolysis of the nucleosidic bond, their C-analogues are much more stable. Several C …

All biological information, since the last common ancestor of all life on Earth, has been
encoded by a genetic alphabet consisting of only four nucleotides that form two base pairs …

Conspectus The information available to any organism is encoded in a four nucleotide, two
base pair genetic code. Since its earliest days, the field of synthetic biology has endeavored …

This paper presents an overview of recent experiments and theoretical developments aimed
at using vibrational spectroscopy to understand the structure and dynamics of nitrile-labeled …

DNA is inherently limited by its four natural nucleotides. Efforts to expand the genetic
alphabet, by addition of an unnatural base pair, promise to expand the biotechnological …

We synthesized C5-modified analogs of 2′-deoxyuridine triphosphate and 2′-
deoxycytidine triphosphate and investigated them as substrates for PCRs using Taq, Tth …

Predominantly hydrophobic unnatural nucleotides that selectively pair within duplex DNA as
well as during polymerase-mediated replication have recently received much attention as …

Biological polymers such as nucleic acids and proteins are ubiquitous in living systems, but
their ability to address problems beyond those found in nature is constrained by factors such …

DNA is not only a repository of genetic information for life, it is also a unique polymer with
remarkable properties: it associates according to well-defined rules, it can be assembled …