Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature

S Wolking, E Schaeffeler, H Lerche, M Schwab… - Clinical …, 2015 - Springer
ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1)
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …

Pharmacokinetic and pharmacodynamic responses to clopidogrel: evidences and perspectives

YJ Zhang, MP Li, J Tang, XP Chen - International Journal of …, 2017 - mdpi.com
Clopidogrel has significantly reduced the incidence of recurrent atherothrombotic events in
patients with acute coronary syndrome (ACS) and in those undergoing percutaneous …

Influence of genetic co-factors on the population pharmacokinetic model for clopidogrel and its active thiol metabolite

D Danielak, M Karaźniewicz-Łada, A Komosa… - European Journal of …, 2017 - Springer
Purpose A high interindividual variability is observed in the pharmacokinetics of clopidogrel,
a widely used antiplatelet drug. In the present study, a joint parent-metabolite population …

Genomewide association study identifies novel genetic loci that modify antiplatelet effects and pharmacokinetics of clopidogrel

WP Zhong, H Wu, JY Chen, XX Li… - Clinical …, 2017 - Wiley Online Library
Genetic variants in the pharmacokinetic (PK) mechanism are the main underlying factors
affecting the antiplatelet response to clopidogrel. Using a genomewide association study …

Circulating MicroRNA profiling in non-ST elevated coronary artery syndrome highlights genomic associations with serial platelet reactivity measurements

KC Becker, LC Kwee, ML Neely, E Grass… - Scientific reports, 2020 - nature.com
Abstract Changes in platelet physiology are associated with simultaneous changes in
microRNA concentrations, suggesting a role for microRNA in platelet regulation. Here we …

Comparison of CYP2C9, CYP2C19, CYP2D6, ABCB1, and SLCO1B1 gene-polymorphism frequency in Russian and Nanai populations

DA Sychev, GN Shuev, SS Suleymanov… - Pharmacogenomics …, 2017 - Taylor & Francis
Background The efficiency and safety of drug therapy depends on the peculiarities of
functioning of the P450 cytochrome group and transporting proteins. There are significant …

The risk of clopidogrel resistance is associated with ABCB1 polymorphisms but not promoter methylation in a Chinese Han population

J Su, Q Yu, H Zhu, X Li, H Cui, W Du, L Ji, M Tong… - PloS one, 2017 - journals.plos.org
The goal of our study was to investigate the contribution of ABCB1 expression to the risk of
clopidogrel resistance (CR). Platelets functions were measured using the Verify-Now P2Y12 …

[HTML][HTML] Association of genetic variations of 3′-UTR in clopidogrel pharmacokinetic-relevant genes with clopidogrel response in Han Chinese patients with coronary …

D Li, B Xiang, J Peng, H Li, L Peng, X Chen - European Journal of …, 2024 - Elsevier
Dual antiplatelet therapy with aspirin and clopidogrel has reduced ischemic vascular events
significantly. Genetic influence, especially those in clopidogrel pharmacokinetic-relevant …

Expression of ATP-binding cassette subfamily B member 1 gene in peripheral blood of patients with acute myocardial infarction

J Ruan, H Meng, Y Chen, Z Yan, X Li, F Meng - Bioengineered, 2022 - Taylor & Francis
This study aimed to determine the amount of expression of the ATP-binding cassette
subfamily B member 1 (ABCB1) gene chip as a prospective diagnostic marker for acute …

Effects of MDR1 1236C> T-2677G> T-3435C> T polymorphisms on the intracellular accumulation of tacrolimus, cyclosporine A, sirolimus and everolimus

R Wang, X Sun, YS Deng, XW Qiu - Xenobiotica, 2019 - Taylor & Francis
Overexpression of P-glycoprotein (P-gp, encoded by MDR1) mediates resistance to multiple
immunosuppressors. Several common MDR1 variants (1236C> T, 2677G> T, 3435C> T) …