Tumor‐targeting glycol chitosan nanoparticles for cancer heterogeneity

JH Ryu, HY Yoon, IC Sun, IC Kwon… - Advanced Materials, 2020 - Wiley Online Library
Nanomedicine is extensively employed for cancer treatment owing to its unique advantages
over conventional drugs and imaging agents. This increased attention to nanomedicine …

Nanoparticles for nucleic acid delivery: Applications in cancer immunotherapy

AJ Mukalel, RS Riley, R Zhang, MJ Mitchell - Cancer letters, 2019 - Elsevier
Immunotherapy has recently emerged as a powerful tool for cancer treatment. Early clinical
successes from cancer immunotherapy have led to a growing list of FDA approvals, and …

Chitosan nanoparticles for nuclear targeting: the effect of nanoparticle size and nuclear localization sequence density

SN Tammam, HME Azzazy, HG Breitinger… - Molecular …, 2015 - ACS Publications
Many recently discovered therapeutic proteins exert their main function in the nucleus, thus
requiring both efficient uptake and correct intracellular targeting. Chitosan nanoparticles …

Synergistic targeting of cell membrane, cytoplasm, and nucleus of cancer cells using rod-shaped nanoparticles

S Barua, S Mitragotri - ACS nano, 2013 - ACS Publications
Design of carriers for effective delivery and targeting of drugs to cellular and subcellular
compartments is an unmet need in medicine. Here, we report pure drug nanoparticles …

Overcoming the barriers of nuclear-targeted drug delivery using nanomedicine-based strategies for enhanced anticancer therapy

SM Roy, V Garg, SP Sivaraman, S Barman… - Journal of Drug Delivery …, 2023 - Elsevier
Targeted drug delivery is critical for improving the therapeutic benefits of anticancer drugs.
The active delivery strategy increases the bioavailability of drugs not only to the diseased …

Guiding drugs to target‐harboring organelles: Stretching drug‐delivery to a higher level of resolution

S Louzoun‐Zada, QZ Jaber, M Fridman - Angewandte Chemie, 2019 - Wiley Online Library
The ratio between the dose of drug required for optimal efficacy and the dose that causes
toxicity is referred to as the therapeutic window. This ratio can be increased by directing the …

Functional chitosan and its derivative-related drug delivery systems for nano-therapy: recent advances

Z Wang, F Yu, F Hu - Pharmaceutics, 2024 - mdpi.com
In the struggle against diseases, the development of nano-therapy has certainly been a
tremendous progression owing to the various superiority, and chitosan is no doubt a kind of …

Doxorubicin and anti-VEGF siRNA co-delivery via nano-graphene oxide for enhanced cancer therapy in vitro and in vivo

Q Sun, X Wang, C Cui, J Li, Y Wang - International Journal of …, 2018 - Taylor & Francis
Background Graphene oxide (GO) has attracted intensive interest in biological and medical
fields in recent years due to its unique physical, chemical, and biological properties. In our …

Simultaneous Sustained Drug Delivery, Tracking, and On-Demand Photoactivation of DNA–Hydrogel Formulated from a Biomass-Derived DNA Nanoparticle

R Shankar, S Nayak, S Singh, A Sen… - ACS Applied Bio …, 2023 - ACS Publications
Conversion of biomass into nanoparticles for meaningful biomedical applications is a
formidable proposition with excellent prospects but fewer patrons. A lack of general …

Aptamer-based liposomes improve specific drug loading and release

K Plourde, RM Derbali, A Desrosiers, C Dubath… - Journal of Controlled …, 2017 - Elsevier
Aptamer technology has shown much promise in cancer therapeutics for its targeting
abilities. However, its potential to improve drug loading and release from nanocarriers has …