EGFR signaling pathway as therapeutic target in human cancers

E Levantini, G Maroni, M Del Re, DG Tenen - Seminars in cancer biology, 2022 - Elsevier
Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …

Present status of microfluidic PCR chip in nucleic acid detection and future perspective

S Chen, Y Sun, F Fan, S Chen, Y Zhang… - TrAC Trends in …, 2022 - Elsevier
Polymerase chain reaction (PCR) amplifies specific fragment of DNA molecules and has
been extensively applied in fields of pathogens and gene mutation detection, food safety …

Isolation and characterization of extracellular vesicles and future directions in diagnosis and therapy

KP De Sousa, I Rossi, M Abdullahi… - Wiley …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are a unique and heterogeneous class of lipid bilayer
nanoparticles secreted by most cells. EVs are regarded as important mediators of …

Purification of HCC-specific extracellular vesicles on nanosubstrates for early HCC detection by digital scoring

N Sun, YT Lee, RY Zhang, R Kao, PC Teng… - Nature …, 2020 - nature.com
We report a covalent chemistry-based hepatocellular carcinoma (HCC)-specific extracellular
vesicle (EV) purification system for early detection of HCC by performing digital scoring on …

Nanomaterial-based microfluidic systems for cancer biomarker detection: recent applications and future perspectives

Y Xiang, C Hu, G Wu, S Xu, Y Li - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Detecting cancer biomarkers (eg, circulating tumor cells, extracellular vehicles, nucleic
acids, and protein biomarkers) is vital for risk assessment and early diagnosis. Nanomaterial …

Resveratrol-loaded macrophage exosomes alleviate multiple sclerosis through targeting microglia

X Zheng, K Sun, Y Liu, X Yin, H Zhu, F Yu… - Journal of Controlled …, 2023 - Elsevier
Despite exosome promise as endogenous drug delivery vehicles, the current understanding
of exosome may be insufficient to develop their various applications. Here we synthesized …

[HTML][HTML] Small extracellular vesicles in cancer

K Abhange, A Makler, Y Wen, N Ramnauth, W Mao… - Bioactive Materials, 2021 - Elsevier
Extracellular vesicles (EV) are lipid-bilayer enclosed vesicles in submicron size that are
released from cells. A variety of molecules, including proteins, DNA fragments, RNAs, lipids …

Microfluidics for detection of exosomes and microRNAs in cancer: State of the art

SM Mousavi, SMA Mahdian, MS Ebrahimi… - … Therapy-Nucleic Acids, 2022 - cell.com
Exosomes are small extracellular vesicles with sizes ranging from 30–150 nanometers that
contain proteins, lipids, mRNAs, microRNAs, and double-stranded DNA derived from the …

Extracellular vesicles as a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance

MH Vasconcelos, HR Caires, A Ābols… - Drug Resistance …, 2019 - Elsevier
Cancer-derived extracellular vesicles (EVs) have been detected in the bloodstream and
other biofluids of cancer patients. They carry various tumor-derived molecules such as …

Advanced nanotechnologies for extracellular vesicle‐based liquid biopsy

L Min, B Wang, H Bao, X Li, L Zhao, J Meng… - Advanced …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are emerging as a new source of biomarkers in liquid biopsy
because of their wide presence in most body fluids and their ability to load cargoes from …