Most antibiotic resistance mechanisms are associated with a fitness cost that is typically
observed as a reduced bacterial growth rate. The magnitude of this cost is the main …

Abstract Treatment of tuberculosis (TB) has been a therapeutic challenge because of not
only the naturally high resistance level of Mycobacterium tuberculosis to antibiotics but also …

This chapter focuses on the impact of antibiotic resistance caused by chromosomal
mutations on bacterial fitness. An approach to estimate the biological costs associated with …

Tuberculosis (TB) has become a curable disease, thanks to the discovery of antibiotics.
However, it has remained one of the most difficult infections to treat. Most current TB …

Campylobacter jejuni, a major foodborne human pathogen, has become increasingly
resistant to fluoroquinolone (FQ) antimicrobials. By using clonally related isolates and …

Compensatory mutations, due to their ability to mask the deleterious effects of another
mutation, are important for the adaptation and evolution of most organisms. Resistance to …

Extensively drug-resistant (XDR) tuberculosis is defined as disease caused by
Mycobacterium tuberculosis with resistance to at least isoniazid and rifampicin, any …

The objectives of this study were to investigate the origin of highly discordant rifampin
(rifampicin)(RMP) drug susceptibility test results obtained for Mycobacterium tuberculosis …

The emergence of drug-resistant pathogens poses a major threat to public health. Although
influenced by multiple factors, high-level resistance is often associated with mutations in …

Globally, tuberculosis (TB) is a leading cause of death from a single infectious agent.
Healthcare workers (HCWs) are at increased risk of hospital-acquired TB infection due to …