Pyridine derivatives as biologically active precursors; organics and selected coordination complexes
E Khan - ChemistrySelect, 2021 - Wiley Online Library
Pyridine (py) is an important heterocyclic compound and is an integral part of various natural
products. There are various medicines containing py ring system being available in the …
products. There are various medicines containing py ring system being available in the …
Small Molecule Inhibitors Targeting the “Undruggable” Survivin: The Past, Present, and Future from a Medicinal Chemist's Perspective
Survivin, a homodimeric protein and a member of the IAP family, plays a vital function in cell
survival and cycle progression by interacting with various proteins and complexes. Its …
survival and cycle progression by interacting with various proteins and complexes. Its …
One-pot synthesis of novel poly-substituted 3-cyanopyridines: Molecular docking, antimicrobial, cytotoxicity, and DFT/TD-DFT studies
Abstract Novel pyridine-3-carbonitrile derivatives, denoted as (4a-j), were synthesized using
a convergent synthetic approach that involved a one-pot four-component reaction. This was …
a convergent synthetic approach that involved a one-pot four-component reaction. This was …
Tailored horseshoe-shaped nicotinonitrile scaffold as dual promising c-Met and Pim-1 inhibitors: Design, synthesis, SAR and in silico study
For the horseshoe tactic to succeed in inhibiting c-Met and Pim-1, the nicotinonitrile
derivatives (2a-n) were produced in high quantities by coupling acetyl phenylpyrazole (1) …
derivatives (2a-n) were produced in high quantities by coupling acetyl phenylpyrazole (1) …
Utilization of cyanopyridine in design and synthesis of first-in-class anticancer dual acting PIM-1 kinase/HDAC inhibitors
AKA Bass, ESM Nageeb, MS El-Zoghbi… - Bioorganic …, 2022 - Elsevier
Herein, we report design and synthesis of twenty-one dual PIM-1/HDAC inhibitors utilizing 3-
cyanopyridines as a novel cap moiety linked with aliphatic/aromatic linker bearing carboxylic …
cyanopyridines as a novel cap moiety linked with aliphatic/aromatic linker bearing carboxylic …
Pyridine moiety: an insight into recent advances in the treatment of cancer
The incidence of cancer is increasing worldwide, affecting a vast majority of the human
population, therefore, new different anticancer agents are being developed now and their …
population, therefore, new different anticancer agents are being developed now and their …
[HTML][HTML] Drug screening and biomarker gene investigation in cancer therapy through the human transcriptional regulatory network
Z He, K Gao, L Dong, L Liu, X Qu, Z Zou, Y Wu… - Computational and …, 2023 - Elsevier
A complex and vast biological network regulates all biological functions in the human body
in a sophisticated manner, and abnormalities in this network can lead to disease and even …
in a sophisticated manner, and abnormalities in this network can lead to disease and even …
Discovery of new cyanopyridine/chalcone hybrids as dual inhibitors of EGFR/BRAFV600E with promising antiproliferative properties
As dual EGFR and BRAFV600E inhibitors, 2‐(3‐cyano‐4, 6‐bis (aryl)‐2‐oxo‐1, 2‐
dihydropyridine‐1‐yl)‐N‐(4‐cinnamoylphenyl) acetamide derivatives 8–20 were developed …
dihydropyridine‐1‐yl)‐N‐(4‐cinnamoylphenyl) acetamide derivatives 8–20 were developed …
Theoretical studies, anticancer activity, and photovoltaic performance of newly synthesized carbazole-based dyes
MR Elmorsy, E Abdel-Latif, HE Gaffer… - Journal of Molecular …, 2022 - Elsevier
We have synthesized a new class of carbazole-based cyanoacetanilides (5a-c) and
carbazole based-thiazolidine derivatives (7a and 7b). These compounds were prepared …
carbazole based-thiazolidine derivatives (7a and 7b). These compounds were prepared …
Cyanopyridinone-and Cyanopyridine-Based Cancer Cell Pim-1 Inhibitors: Design, Synthesis, Radiolabeling, Biodistribution, and Molecular Modeling Simulation
In this study, two new series of 3-cyanopyridinones (3a–e) and 3-cyanopyridines (4a–e)
were synthesized and evaluated for their cytotoxicity and Pim-1 kinase inhibitory activity …
were synthesized and evaluated for their cytotoxicity and Pim-1 kinase inhibitory activity …