DNA compaction: fundamentals and applications

A Estévez-Torres, D Baigl - Soft Matter, 2011 - pubs.rsc.org
Compaction is the process in which a large DNA molecule undergoes a transition between
an elongated conformation and a very compact form. In nature, DNA compaction occurs to …

Coarse-grained modeling of ion-containing polymers

Z Zhu, X Luo, SJ Paddison - Chemical Reviews, 2022 - ACS Publications
Ion-containing polymers have continued to be an important research focus for several
decades due to their use as an electrolyte in energy storage and conversion devices …

Entropy and enthalpy of polyelectrolyte complexation: Langevin dynamics simulations

Z Ou, M Muthukumar - The Journal of chemical physics, 2006 - pubs.aip.org
We report a systematic study by Langevin dynamics simulation on the energetics of
complexation between two oppositely charged polyelectrolytes of same charge density in …

Modeling the multivalent recognition between dendritic molecules and DNA: understanding how ligand “sacrifice” and screening can enhance binding

GM Pavan, A Danani, S Pricl… - Journal of the American …, 2009 - ACS Publications
This paper reports the application of molecular dynamics methods to understand the
interactions between dendritic molecules with spermine surface groups and double-helical …

Chitosan–hyaluronic acid nanoparticles for gene silencing: The role of hyaluronic acid on the nanoparticles' formation and activity

S Al-Qadi, M Alatorre-Meda, EM Zaghloul… - Colloids and Surfaces B …, 2013 - Elsevier
Hyaluronic acid (HA) has been described as a biocompatibility enhancer for gene delivery
systems; however, the mechanistic implications of its inclusion on the formation and activity …

Artificial Intelligence (AI)-Aided Structure Optimization for Enhanced Gene Delivery: The Effect of the Polymer Component Distribution (PCD)

Y Li, Z He, X Wang, Z Li, M Johnson… - … Applied Materials & …, 2023 - ACS Publications
Gene therapy has emerged as a significant advancement in medicine in recent years.
However, the development of effective gene delivery vectors, particularly polymer vectors …

Coil− globule transition of DNA molecules induced by cationic surfactants: A dynamic light scattering study

RS Dias, J Innerlohinger, O Glatter… - The Journal of …, 2005 - ACS Publications
The compaction and aggregation of DNA induced by cationic surfactants was studied by
dynamic light scattering (DLS). Furthermore, the effect on surfactant-compacted DNA of the …

[HTML][HTML] Molecular dynamics simulations of DNA-polycation complex formation

J Ziebarth, Y Wang - Biophysical journal, 2009 - cell.com
Complexes formed from DNA and polycations are of interest because of their potential use
in gene therapy; however, there remains a lack of understanding of the structure and …

Photosensitive surfactants with various hydrophobic tail lengths for the photocontrol of genomic DNA conformation with improved efficiency

A Diguet, NK Mani, M Geoffroy… - … A European Journal, 2010 - Wiley Online Library
We report the synthesis and characterisation of photosensitive cationic surfactants with
various hydrophobic tail lengths. These molecules, called AzoCx, are used as …

DNA condensation by peptide-conjugated PAMAM dendrimers. influence of peptide charge

C Dannert, I Mardal, R Lale, BT Stokke, RS Dias - ACS omega, 2023 - ACS Publications
Nucleic acid delivery to cells is an important therapeutic strategy that requires the transport
of nucleic acids to intracellular compartments and their protection from enzymatic …