The lysosome-mediated degradation pathway known as macroautophagy is the most
versatile means through which cells can eliminate and recycle unwanted materials. Through …

Neurotrophins are a family of proteins that are important for neuronal development, neuronal
survival and neuronal functions. Neurotrophins exert their role by binding to their receptors …

Autophagy is an essential cellular pathway for degrading defective organelles and
aggregated proteins. Defects in autophagy have been implicated in the neurodegenerative …

Huntington's Disease (HD) is an autosomal dominant progressive neurodegenerative
disorder characterized by cognitive, behavioral and motor dysfunctions. HD is caused by a …

In the developing cortex, projection neurons undergo multipolar-bipolar transition, radial-
directed migration, and maturation. The contribution of these developmental steps to the …

Huntington's disease (HD) is characterized by protein inclusions and loss of striatal neurons
which result from expanded CAG repeats in the poly-glutamine (polyQ) region of the …

Huntingtin (HTT) is an essential protein during early embryogenesis and the development of
the central nervous system (CNS). Conditional knock-out of mouse Huntingtin (Htt) …

Huntington's disease (HD) is a devastating dominantly inherited neurodegenerative disorder
caused by an abnormal polyglutamine expansion in the N-terminal part of the huntingtin …

Membrane/protein trafficking in the secretory/biosynthetic and endocytic pathways is
mediated by vesicles. Vesicle trafficking in eukaryotes is regulated by a class of small …

Loss of huntingtin (HTT), the Huntington's disease (HD) protein, was previously shown to
cause axonal transport defects. Within axons, HTT can associate with kinesin-1 and dynein …