Building dry powder formulations using supercritical CO2 spray drying

A Aguiar-Ricardo - Current Opinion in Green and Sustainable Chemistry, 2017 - Elsevier
Highlights•ScCO 2-assisted spray drying (SASD) brings additional advantages as compared
to conventional SD.•SASD improves the aerodynamic performance of dry powder inhaler …

From batch to continuous—New opportunities for supercritical CO2 technology in pharmaceutical manufacturing

B Long, KM Ryan, L Padrela - European Journal of Pharmaceutical …, 2019 - Elsevier
Poor solubility and bioavailability of new chemical entities is a major challenge that keeps
plaguing the pharmaceutical industry and jeopardizes their away to the market …

Solid dosage forms of biopharmaceuticals in drug delivery systems using sustainable strategies

C Costa, T Casimiro, ML Corvo, A Aguiar-Ricardo - Molecules, 2021 - mdpi.com
Drug delivery systems (DDS) often comprise biopharmaceuticals in aqueous form, making
them susceptible to physical and chemical degradation, and therefore requiring low …

Core–shell polycationic polyurea pharmadendrimers: New-generation of sustainable broad-spectrum antibiotics and antifungals

SN Pinto, D Mil-Homens, RF Pires, MM Alves… - Biomaterials …, 2022 - pubs.rsc.org
The efficacy of conventional antimicrobials is falling to critical levels and raising alarming
concerns around the globe. In this scenery, engineered nanoparticles emerged as a solid …

Assessing the impact and suitability of dense carbon dioxide as a green solvent for the treatment of PMMA of historical value

A Bartoletti, I Soares, AM Ramos, Y Shashoua, A Quye… - Polymers, 2023 - mdpi.com
Surface cleaning of plastic materials of historical value can be challenging due to the high
risk of inducing detrimental effects and visual alterations. As a result, recent studies have …

Nano‐in‐Micro POxylated Polyurea Dendrimers and Chitosan Dry Powder Formulations for Pulmonary Delivery

RB Restani, AS Silva, RF Pires… - Particle & Particle …, 2016 - Wiley Online Library
Pulmonary administration offers excellent advantages over conventional drug delivery
routes, including increasing therapeutics bioavailability, and avoiding long‐term safety …

Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates: In Vivo Virulence Assessment in Galleria mellonella and Potential Therapeutics by Polycationic …

D Mil-Homens, M Martins, J Barbosa, G Serafim… - Antibiotics, 2021 - mdpi.com
Klebsiella pneumoniae, one of the most common pathogens found in hospital-acquired
infections, is often resistant to multiple antibiotics. In fact, multidrug-resistant (MDR) K …

Development of PLGA dry powder microparticles by supercritical CO2-assisted spray-drying for potential vaccine delivery to the lungs

M Tavares, RP Cabral, C Costa, P Martins… - The Journal of …, 2017 - Elsevier
In this work, biocompatible and biodegradable poly (dl-lactide-co-glycolide)(PLGA)
composite microparticles with potential use as carrier for vaccines and other drugs to the …

[HTML][HTML] Recriar-se lúdico no desenvolvimento de jogos na saúde: referências teórico-metodológicas à produção de subjetividades críticas

MRGM Pires, LBD Gottems… - Texto & Contexto …, 2017 - SciELO Brasil
Objetivo: refletir sobre a centralidade do lúdico na reinvenção de subjetividades críticas na
área da saúde; apresentar, com base no referencial elaborado e nos relatos de experiência …

Significant solubility of carbon dioxide in Soluplus® facilitates impregnation of ibuprofen using supercritical fluid technology

R Obaidat, M Alnaief, P Jaeger - Pharmaceutical development and …, 2018 - Taylor & Francis
Abstract Treatment of Soluplus® with supercritical carbon dioxide allows promising
applications in preparing dispersions of amorphous solids. Several characterization …