Nucleic acid sensing is a critical mechanism by which the immune system monitors for
pathogen invasion. A set of germline‐encoded innate immune receptors detect microbial …

Recognition of DNA by the cell is an important immunological signature that marks the
initiation of an innate immune response. AIM2 is a cytoplasmic sensor that recognizes …

Francisella tularensis is the causative agent of the acute disease tularemia. Due to its
extreme infectivity and ability to cause disease upon inhalation, F. tularensis has been …

Intracellular bacterial pathogens cause a wide range of diseases and significantly contribute
to the morbidity and mortality associated with infectious diseases worldwide (1‐16)(Table 1) …

Primary interaction of an intracellular bacterium with its host cell is initiated by activation of
multiple signaling pathways in response to bacterium recognition itself or as cellular …

Early sensing of pathogenic bacteria by the host immune system is important to develop
effective mechanisms to kill the invader. Microbial recognition, activation of signaling …

Activation of the inflammasome occurs in response to a notably high number of pathogenic
microbes and is a broad innate immune response that effectively contributes to restriction of …

Maintenance of immune homeostasis is an intricate process wherein inflammasomes play a
pivotal role by contributing to innate and adaptive immune responses. Inflammasomes are …

Activation of the inflammasome occurs in response to infection with a wide array of
pathogenic microbes. The inflammasome serves as a platform to activate caspase-1, which …

Francisella tularensis is a facultative intracellular pathogen, and is the causative agent of a
fatal human disease known as tularemia. F. tularensis is classified as a Category A Biothreat …