Tissue injury disrupts the mechanical homeostasis that underlies normal tissue architecture
and function. The failure to resolve injury and restore homeostasis gives rise to progressive …

In response to myocardial infarction (MI), the wound healing response of the left ventricle
(LV) comprises overlapping inflammatory, proliferative, and maturation phases, and the …

Cardiac fibroblasts help maintain the normal architecture of the healthy heart and are
responsible for scar formation and the healing response to pathological insults. Various …

Fibrosis is an exaggerated form of tissue repair that occurs with serious damage or repetitive
injury and ultimately leads to organ failure due to the excessive scarring. Increased calcium …

Over a decade ago, mutations in the gene encoding TRPC6 (transient receptor potential
cation channel, subfamily C, member 6) were linked to development of familial forms of …

The transient receptor potential (TRP) channel superfamily consists of a large group of non-
selective cation channels that serve as cellular sensors for a wide spectrum of physical and …

Background During kidney fibrosis, a hallmark and promoter of CKD (regardless of the
underlying renal disorder leading to CKD), the extracellular-regulated kinase 1/2 (ERK1/2) …

Bone-derived fibroblast growth factor 23 (FGF23) is an important endocrine regulator of
mineral homeostasis with effects transduced by cognate FGF receptor (FGFR) 1-α-Klotho …

Cardiac fibrosis is the excessive deposition of extracellular matrix proteins by cardiac
fibroblasts and myofibroblasts, and is a hallmark feature of most heart diseases, including …

Several reports previously investigated the Transient Receptor Potential Canonical
subfamily channel 3 (TRPC3) in the kidney. However, most of the conclusions are based on …