Next-generation DNA sequencing technology has dramatically advanced clinical oncology
through the identification of therapeutic targets and molecular biomarkers, leading to the …

Carcinomas are complex heterocellular systems containing epithelial cancer cells, stromal
fibroblasts, and multiple immune cell‐types. Cell‐cell communication between these tumor …

Fibroblasts display extensive transcriptional heterogeneity, yet functional annotation and
characterization of their heterocellular relationships remains incomplete. Using mass …

ANPELA is widely used for quantifying traditional bulk proteomic data. Recently, there is a
clear shift from bulk proteomics to the single‐cell ones (SCP), for which powerful cytometry …

The development of vaccines, which prime the immune system to respond to future
infections, has led to global declines in morbidity and mortality from dreadful infectious …

Profiling protein expression at single‐cell resolution is essential for fundamental biological
research (such as cell differentiation and tumor microenvironmental examination) and …

Metastatic melanoma remains an incurable disease for many patients due to the limited
success of targeted and immunotherapies. BRAF and MEK inhibitors reduce metastatic …

Most of our understanding regarding the involvement of SRC-family tyrosine kinases in
cancer has stemmed from studies focused on the prototypical SRC oncogene. However …

Signaling networks process intra-and extracellular information to modulate the functions of a
cell. Deregulation of signaling networks results in abnormal cellular physiological states and …

Originally described as interpatient variability, tumour heterogeneity has now been
demonstrated to occur intrapatiently, within the same lesion, or in different lesions of the …