Epilepsy is a complex neurological syndrome characterized by neuronal hyperexcitability
and sudden, synchronized electrical discharges that can manifest as seizures. It is now …

Seizures result from hypersynchronous, abnormal firing of neuronal populations and are the
primary clinical symptom of the epilepsies. Brain tissue from animal models and patients …

Adenosine is a well-characterized endogenous anticonvulsant and seizure terminator of the
brain. Through a combination of adenosine receptor-dependent and-independent …

Sudden unexpected death in epilepsy (SUDEP) is a major cause of death in people with
epilepsy (PWE). Postictal apnea leading to cardiac arrest is the most common sequence of …

Oxygen is delivered to brain tissue by a dense network of microvessels, which actively
control cerebral blood flow (CBF) through vasodilation and contraction in response to …

Comorbidities in Neurology represent a major conceptual and therapeutic challenge. For
example, temporal lobe epilepsy (TLE) is a syndrome comprised of epileptic seizures and …

Brain somatic mutations confer genomic diversity in the human brain and cause
neurodevelopmental disorders. Recently, brain somatic activating mutations in MTOR have …

Astrocytes play a dual role in the brain. On the one hand, they are active signaling partners
of neurons and can for instance control synaptic transmission and its plasticity. On the other …

Adenosinergic activities are suggested to participate in SUDEP pathophysiology; this study
aimed to evaluate the adenosine hypothesis of SUDEP and specifically the role of …

The successful identification of promising investigational therapies for the treatment of
epilepsy can be credited to the use of numerous animal models of seizure and epilepsy for …