MicroRNAs (miRNAs) are pervasively expressed and regulate most biological functions.
They function by modulating transcriptional and translational programs and therefore they …

Control of mRNA translation plays a crucial role in the regulation of gene expression and is
critical for cellular homeostasis. Dysregulation of translation initiation factors has been …

Malignant mesothelioma (MpM) is an aggressive, invariably fatal tumour that is causally
linked with asbestos exposure. The disease primarily results from loss of tumour suppressor …

In tumourigenesis, oncogenes or dysregulated tumour suppressor genes alter the canonical
translation machinery leading to a reprogramming of the translatome that, in turn, promotes …

The translational capability of ribosomes deprived of specific nonfundamental ribosomal
proteins may be altered. Physiological mechanisms are scanty, and it is unclear whether …

The repertoire of extratranslational functions of components of the protein synthesis
apparatus is expanding to include control of key cell signaling networks. However, very little …

Removal of colorectal adenomas is an effective strategy to reduce colorectal cancer (CRC)
mortality rates. However, as only a minority of adenomas progress to cancer, such strategies …

Background Although eukaryotic initiation factor 6 (eIF6) is a novel therapeutic target, data
on its importance in the development of esophageal carcinoma (ESCA) remains limited. This …

Eukaryotic elongation factor 1A1 (EEF1A1) is canonically involved in protein synthesis, but
also has non-canonical functions in diverse cellular processes. Previously, we identified …

Non–small cell lung cancer (NSCLC) is the leading cause of cancer-related death
worldwide. Dysregulation of protein synthesis plays a major role in carcinogenesis, a …