The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Osteoarthritis (OA) and degenerative disc disease (DDD) are similar diseases involving the
breakdown of cartilage tissue, and a better understanding of the underlying biochemical …

Synovial sarcoma (SS) is defined by the hallmark SS18-SSX fusion oncoprotein, which
renders BAF complexes aberrant in two manners: gain of SSX to the SS18 subunit and …

Synovial sarcoma is an aggressive cancer invariably associated with a chromosomal
translocation involving genes encoding the SWI-SNF complex component SS18 and an SSX …

Oncogenesis in synovial sarcoma is driven by the chromosomal translocation t (X, 18; p11,
q11), which generates an in-frame fusion of the SWI/SNF subunit SS18 to the C-terminal …

Rare but recurrent mutations in the fibroblast growth factor receptor (FGFR) pathways, most
commonly in one of the four FGFR receptor tyrosine kinase genes, can potentially be …

Background Soft tissue sarcoma (STS) diagnosis is challenging because of a multitude of
histopathological subtypes, different genetic characteristics, and frequent intratumoral …

Despite their shared predilection for superficial soft tissue of distal extremities and frequent
local recurrences, myxoinflammatory fibroblastic sarcoma (MIFS) and hemosiderotic …

The fibroblast growth factor receptor (FGFR) family includes four highly conserved receptor
tyrosine kinases: FGFR1–4. Upon ligand binding, FGFRs activate an array of downstream …

Myxoinflammatory fibroblastic sarcoma (MIFS) is a low‐grade malignant neoplasm for which
limited genetic information, including at (1; 10)(p22; q24) and amplification of chromosome 3 …