In contrast to single-cell approaches for measuring gene expression and DNA accessibility,
single-cell methods for analyzing histone modifications are limited by low sensitivity and …

The chromosomally-arrayed Hox gene family plays central roles in embryonic patterning
and the specification of cell identities throughout the animal kingdom. In vertebrates, the …

Myelination has evolved as a mechanism to ensure fast and efficient propagation of nerve
impulses along axons. Within the central nervous system (CNS), myelination is carried out …

OLIG2 is a transcription factor that activates the expression of myelin-associated genes in
the oligodendrocyte-lineage cells. However, the mechanisms of myelin gene inactivation are …

The intracellular cholesterol transporter NPC1 functions in late endosomes and lysosomes
to efflux unesterified cholesterol, and its deficiency causes Niemann–Pick disease Type C …

Polycomb repressive complexes (PRCs) 1 and 2 maintain stable cellular memories of early
fate decisions by establishing heritable patterns of gene repression. PRCs repress …

The epigenetic landscape of oligodendrocyte lineage cells refers to the cell‐specific
modifications of DNA, chromatin, and RNA that define a unique gene expression pattern of …

Glioma cells hijack developmental programs to control cell state. Here, we uncover a glioma
cell state-specific metabolic liability that can be therapeutically targeted. To model cell …

Oligodendrocytes (OLs) produce myelin in the central nervous system (CNS), which
accelerates the propagation of action potentials and supports axonal integrity. As a major …

Proper axonal myelination and function of the vertebrate central nervous system rely largely
on the timely differentiation of oligodendrocytes (OLs), yet key regulatory factors remain …