Alpha-synuclein aggregation in Parkinson's disease

E Srinivasan, G Chandrasekhar… - Frontiers in …, 2021 - frontiersin.org
Parkinson's disease (PD), a neurodegenerative disorder characterized by distinct aging-
independent loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) region …

Advances in the understanding of protein misfolding and aggregation through molecular dynamics simulation

A Rahman, B Saikia, CR Gogoi, A Baruah - Progress in Biophysics and …, 2022 - Elsevier
Aberrant protein folding known as protein misfolding is counted as one of the striking factors
of neurodegenerative diseases. The extensive range of pathologies caused by protein …

Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface

KJ Wert, G Velez, MR Cross, BA Wagner… - Free Radical Biology …, 2018 - Elsevier
Oxidative stress is a pathogenic feature in vitreoretinal disease. However, the ability of the
inner retina to manage metabolic waste and oxidative stress is unknown. Proteomic analysis …

Comparative binding of kaempferol and kaempferide on inhibiting the aggregate formation of mutant (G85R) SOD1 protein in familial amyotrophic lateral sclerosis: A …

E Srinivasan, R Rajasekaran - BioFactors, 2018 - Wiley Online Library
Abstract Mutation in Cu/Zn superoxide dismutase (SOD1) at position 85 from glycine to
arginine was found to be a prominent cause of aggregation characterized by an increased …

A systematic and comprehensive review on disease-causing genes in amyotrophic lateral sclerosis

E Srinivasan, R Rajasekaran - Journal of Molecular Neuroscience, 2020 - Springer
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder and is characterized by
degeneration and axon loss from the upper motor neuron, that descends from the lower …

Biochemical and biophysical properties of the novel ALS-linked hSOD1 mutants: an experimental study accompanied by in silico analysis

N Namadyan, B Seyedalipour, S Hosseinkhani… - Journal of the Iranian …, 2023 - Springer
Familial amyotrophic lateral sclerosis (fALS) is a neurodegenerative disorder; approximately
20% are caused by dominant mutations in the gene encoding Cu/Zn human superoxide …

Allura red rapidly induces amyloid-like fibril formation in hen egg white lysozyme at physiological pH

NA Al-Shabib, JM Khan, A Malik, P Sen… - International journal of …, 2019 - Elsevier
Allura red (AR) is an artificial azo dye mostly used in food industries and has potential health
risks. We examined the role of AR in amyloidogenesis using hen egg white lysozyme …

Quantum chemical and molecular mechanics studies on the assessment of interactions between resveratrol and mutant SOD1 (G93A) protein

E Srinivasan, R Rajasekaran - Journal of computer-aided molecular …, 2018 - Springer
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that has been
associated with mutations in metalloenzyme superoxide dismutase (SOD1) causing protein …

[HTML][HTML] Development of in silico analysis and molecular dynamics simulation on L67P and D76Y mutants of the human superoxide dismutase 1 (hSOD1) related to …

P Baziyar, B Seyedalipour… - Iranian Journal of …, 2022 - ncbi.nlm.nih.gov
Background: One neurodegenerative disorder that is caused by a mutation in the hSOD1
gene is Amyotrophic lateral sclerosis (ALS). Objectives: The current study was developed in …

Could Dermaseptin analogue be a competitive inhibitor for ACE2 towards binding with viral spike protein causing COVID19?: computational investigation

PC Sekar, R Rajasekaran - International Journal of Peptide Research and …, 2021 - Springer
Initial phase of COVID-19 infection is associated with the binding of viral spike protein S1
receptor binding domain (RBD) with the host cell surface receptor, ACE2. Peptide inhibitors …