SET for life: biochemical activities and biological functions of SET domain-containing proteins
HM Herz, A Garruss, A Shilatifard - Trends in biochemical sciences, 2013 - cell.com
SET domain-containing proteins belong to a group of enzymes named after a common
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of …
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of …
The regulation and function of histone crotonylation
A Ntorla, JR Burgoyne - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Histone crotonylation is a newly identified epigenetic modification that has a pronounced
ability to regulate gene expression. It belongs to an expanding group of short chain lysine …
ability to regulate gene expression. It belongs to an expanding group of short chain lysine …
REST and stress resistance in ageing and Alzheimer's disease
Human neurons are functional over an entire lifetime, yet the mechanisms that preserve
function and protect against neurodegeneration during ageing are unknown. Here we show …
function and protect against neurodegeneration during ageing are unknown. Here we show …
Long noncoding RNA as modular scaffold of histone modification complexes
Long intergenic noncoding RNAs (lincRNAs) regulate chromatin states and epigenetic
inheritance. Here, we show that the lincRNA HOTAIR serves as a scaffold for at least two …
inheritance. Here, we show that the lincRNA HOTAIR serves as a scaffold for at least two …
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
The development of selective histone deacetylase (HDAC) inhibitors with anti-cancer and
anti-inflammatory properties remains challenging in large part owing to the difficulty of …
anti-inflammatory properties remains challenging in large part owing to the difficulty of …
The histone H3 lysine 9 methyltransferases G9a and GLP regulate polycomb repressive complex 2-mediated gene silencing
C Mozzetta, J Pontis, L Fritsch, P Robin, M Portoso… - Molecular cell, 2014 - cell.com
G9a/GLP and Polycomb Repressive Complex 2 (PRC2) are two major epigenetic silencing
machineries, which in particular methylate histone H3 on lysines 9 and 27 (H3K9 and …
machineries, which in particular methylate histone H3 on lysines 9 and 27 (H3K9 and …
A subset of the histone H3 lysine 9 methyltransferases Suv39h1, G9a, GLP, and SETDB1 participate in a multimeric complex
L Fritsch, P Robin, JRR Mathieu, M Souidi, H Hinaux… - Molecular cell, 2010 - cell.com
Summary Lysine 9 of histone 3 (H3K9) can be mono-, di-, or trimethylated, inducing distinct
effects on gene expression and chromatin compaction. H3K9 methylation can be mediated …
effects on gene expression and chromatin compaction. H3K9 methylation can be mediated …
Relationship among DNA double‐strand break (DSB), DSB repair, and transcription prevents genome instability and cancer
A Ui, N Chiba, A Yasui - Cancer science, 2020 - Wiley Online Library
DNA double‐strand break (DSB) is a serious type of DNA damage and is known to trigger
multiple responses within cells. In these responses, novel relationships among DSB, DSB …
multiple responses within cells. In these responses, novel relationships among DSB, DSB …
MYC interacts with the G9a histone methyltransferase to drive transcriptional repression and tumorigenesis
MYC is an oncogenic driver that regulates transcriptional activation and repression.
Surprisingly, mechanisms by which MYC promotes malignant transformation remain …
Surprisingly, mechanisms by which MYC promotes malignant transformation remain …
Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells
The histone H3 Lys 9 (H3K9) methyltransferase Eset is an epigenetic regulator critical for the
development of the inner cell mass (ICM). Although ICM-derived embryonic stem (ES) cells …
development of the inner cell mass (ICM). Although ICM-derived embryonic stem (ES) cells …