Tissue fibrosis is a key factor leading to disability and death worldwide; however, thus far,
there are no approved treatments for fibrosis. Transforming growth factor (TGF)-β is a major …

Cystic fibrosis (CF) is a multiorgan, genetic disease resulting from dysfunction of the CF
transmembrane conductance regulator. The primary clinical manifestations are …

One of the most important clinical obstacles in cystic fibrosis (CF) treatment is antibiotic
treatment failure due to biofilms produced by Pseudomonas aeruginosa. The ability of this …

Background Body mass index (BMI) correlates with clinical outcomes in cystic fibrosis but
has limitations. Body composition aberrations in CF are multifactorial. We sought to evaluate …

Background Cystic fibrosis (CF) contributes a significant economic burden on individuals,
healthcare systems, and society. Understanding the economic impact of CF is crucial for …

Background: Cystic fibrosis (CF) is a life-limiting genetic disease that causes chronic lung
infections. We developed an internet-based decision aid (DA) to help patients with CF make …

Lead identification and optimization are essential steps in the development of a new drug. It
requires cost-effective, selective and sensitive chemical tools. Here, we report a novel …

Background Cystic fibrosis (CF) is an autosomal recessive disorder caused by CF
transmembrane conductance regulator (CFTR) genetic variants. CFTR modulators improve …

To prevent or mitigate chronic illness burden, people with cystic fibrosis (pwCF) and their
family caregivers need primary (generalist-level) palliative care from the time of diagnosis …

Pain is a complex, multidimensional process that negatively affects physical and mental
functioning, clinical outcomes, quality of life, and productivity for cystic fibrosis (CF) patients …