Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production
With an increasing demand for efficacious, safe, and affordable vaccines for human and
animal use, process intensification in cell culture-based viral vaccine production demands …
animal use, process intensification in cell culture-based viral vaccine production demands …
Oxygen mass transfer in biopharmaceutical processes: numerical and experimental approaches
Oxygen supply in aerobic bioprocesses is of crucial importance. For this reason, this paper
presents the oxygen demand of different cells and summarizes experimental and numerical …
presents the oxygen demand of different cells and summarizes experimental and numerical …
A holistic approach for process intensification of nicotinamide mononucleotide production via high cell density cultivation under exponential feeding strategy
Nicotinamide mononucleotide (NMN) subsists in all living organisms and has drawn
tremendous attention as a nutraceutical and pharmaceutical product for several diseases …
tremendous attention as a nutraceutical and pharmaceutical product for several diseases …
AAV process intensification by perfusion bioreaction and integrated clarification
JP Mendes, B Fernandes, E Pineda… - … in Bioengineering and …, 2022 - frontiersin.org
Adeno-associated viruses (AAVs) demand for clinical trials and approved therapeutic
applications is increasing due to this vector's overall success and potential. The high doses …
applications is increasing due to this vector's overall success and potential. The high doses …
[PDF][PDF] Process intensification strategies toward cell culture‐based high‐yield production of a fusogenic oncolytic virus
We present a proof‐of‐concept study for production of a recombinant vesicular stomatitis
virus (rVSV)‐based fusogenic oncolytic virus (OV), rVSV‐Newcastle disease virus (NDV), at …
virus (rVSV)‐based fusogenic oncolytic virus (OV), rVSV‐Newcastle disease virus (NDV), at …
Influence of HEK293 metabolism on the production of viral vectors and vaccine
Mammalian cell cultures are increasingly used for the production of complex
biopharmaceuticals including viral vectors and vaccines. HEK293 is the predominant cell …
biopharmaceuticals including viral vectors and vaccines. HEK293 is the predominant cell …
[HTML][HTML] Determination of culture design spaces in shaken disposable cultivation systems for CHO suspension cell cultures
RW Maschke, S Seidel, T Bley, R Eibl, D Eibl - Biochemical Engineering …, 2022 - Elsevier
Processes involving mammalian cell cultures-especially CHO suspension cells-dominate
biopharmaceutical manufacturing. These processes are usually developed in small scale …
biopharmaceutical manufacturing. These processes are usually developed in small scale …
Low shear stress increases recombinant protein production and high shear stress increases apoptosis in human cells
Human embryonic kidney cells HEK293 can be used for the production of therapeutic
glycoproteins requiring human post-translational modifications. High cell density perfusion …
glycoproteins requiring human post-translational modifications. High cell density perfusion …
Perfusion processes
V Chotteau - Animal cell culture, 2015 - Springer
The interest for perfusion is increasing nowadays. This new focus has emerged from a
synergy of a demand for disposable equipment and the availability of robust cell separation …
synergy of a demand for disposable equipment and the availability of robust cell separation …
Accelerated and intensified manufacturing of an adenovirus‐vectored vaccine to enable rapid outbreak response
CCD Joe, RR Segireddy, C Oliveira… - Biotechnology and …, 2024 - Wiley Online Library
Abstract The Coalition for Epidemic Preparedness Innovations'“100‐day moonshot” aspires
to launch a new vaccine within 100 days of pathogen identification, followed by large‐scale …
to launch a new vaccine within 100 days of pathogen identification, followed by large‐scale …